The Kharasch et al. editorial is very timely because there is pain with its physical, psychologic, socioeconomic, and spiritual constituents and then there is suffering attributable to pain’s physical, psychologic, socioeconomic, and spiritual consequences.1,2  It is ironic that the evolving opioid epidemic may have created an anomaly. Herein overregulated medical practices to contain overzealous prescription of analgesics may be paradoxically inducing iatrogenic pain and thence iatrogenic suffering leading to iatrogenic suicide ideations, behaviors, attempts, and completions. Can it be safely said that no one ideates, behaves, or attempts to commit suicide unless in pain and suffering? Even those who ritually or culturally presume their completion of life as an indication to take the leap of faith toward ending that life may be suffering as a result of spiritual pain associated with futility...

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