We would like to thank Dr. Sneyd and Prof. Evered for their interesting comments regarding our recent article which assessed the feasibility and potential impact of automated closed-loop anesthesia management on short- and mid-term cognitive function after noncardiac surgery.1,2 

We agree with these authors that an alternative interpretation of our results could be that automated anesthetic management using the combination of three controllers had no impact on delayed neurocognitive recovery. In correspondence with the Journal’s Statistical Editor, the most valid treatment estimate for change in cognition score (the 30-item Montreal Cognitive Assessment) from baseline would be an analysis of covariance, using preoperative cognition score as a covariate and group assignment as a fixed effect. In line with Journal policy, this analysis was labeled as a post hoc sensitivity analysis, as it was requested after...

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