We thank Dr. Grocott for his interest in our article. We share his stated commitment to the core tenets of clear and transparent reporting that support scientific reproducibility. In pursuit of this commitment, we preregistered (NCT02856594) and published the parent clinical trial protocol, including key elements of the statistical analysis plan, and clearly communicated the context of the analyses underlying our retrospective cohort substudy.

Dr. Grocott’s concerns primarily relate to our stated hypotheses and the accompanying inferential framework, finalizing our inferential framework after data access, and the positive results we emphasized. We contend that Dr. Grocott’s letter raises some of the challenges inherent to the closed peer review process and the need for continued education on the nuances innate to interpreting multivariable regression models. At initial submission, we hypothesized an association between cognitive...

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