We thank Joosten et al.1 for their letter to the editor. We read their comments with interest.
We realize that at the time of publication, work had been published on the association between acute kidney injury (AKI) and blood pressure targets in the operating room; however, when the study was designed, this association had not yet come to light. For this reason, we did not incorporate hemodynamic parameter analysis in our primary outcome.
In response to the second comment, the protocol was executed by a limited number of anesthesiologists, all of whom had contributed to the design of the protocol, which should have assured a greater compliance. But we will have a more definitive answer on compliance rate after we have finished our in-depth analysis of all hemodynamic measures.
Additionally, we thank Wuethrich et al...