We read the excellent review “Cryoneurolysis and Percutaneous Peripheral Nerve Stimulation to Treat Acute Pain” with a particular interest in the potential application of neuromodulation for acute pain management. With the accelerating drive for early mobilization and hospital discharge, there is a need to explore alternative pain management strategies in addition to the traditional loco-regional techniques using chemical means to interrupt nerve conduction. Loco-regional analgesic techniques may often result in undesirable effect of motor weakness hindering mobilization or physiotherapy. The infusion of local anesthetics has additional concerns of sterility of the infused solution and the temporal limitation of the duration of infusion. We concur with the authors that analgesic effects with neuromodulation opens a new avenue in augmenting the quality of analgesia while minimizing the risk of motor blockade. Rather than selecting one modality over another,...

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