WE sincerely thank Drs. Kehlet and Foss1 for their commentary on our study2 of the determinants of postoperative pain trajectories. The authors correctly highlight that, although we were able to provide a detailed analysis of pre- and intraoperative characteristics, our study did not robustly characterize postoperative pain management and its relation to postoperative pain trajectories. In the analysis we were able to perform and present, we provided support for a relationship between postoperative opioid requirement and postoperative pain trajectory (Kruskal-Wallis H = 54.8, df = 4, P < 0.001), with patients in the higher pain trajectories requiring greater postoperative opioids (fig. 1, with numbers from Table 3 in the original article2 ). However, as the authors note, with our heterogenous patient sample, there was similar heterogeneity in postoperative pain management, limiting our analysis. We agree with the authors that studies with more homogenous patient populations...
Acute Postoperative Pain Trajectory Groups: Reply
(Accepted for publication June 2, 2021. Published online first on July 16, 2021.)
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Terrie Vasilopoulos, Patrick J. Tighe; Acute Postoperative Pain Trajectory Groups: Reply. Anesthesiology 2021; 135:547–548 doi: https://doi.org/10.1097/ALN.0000000000003874
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