We appreciate Forget et al., Ingrande and Drummond, and Fettiplace and Gitman for their interest in our work. As noticed by the authors, we chose to not administer a nonsteroidal anti-inflammatory drug to facilitate the recruitment of patients in the study. However, we agree that nonsteroidal anti-inflammatory drugs should be administered whenever possible. We also chose to not administer regional anesthesia in patients included in the Postoperative and Opioid-free Anesthesia (POFA) study because they were already receiving intravenous lidocaine. Another study replacing intravenous lidocaine by regional anesthesia would, of course, be of interest. It was perhaps not clearly stated in our article, but the dosage of dexmedetomidine was adapted not according to the Analgesia Nociception Index but rather according to the patient’s heart rate. This was decided in the original design because...

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