We thank Forget et al. and Ingrande and Drummond for their interest in our review on perioperative opioid administration. Forget et al. contend that we did not distinguish between opioid-free anesthesia and opioid-free analgesia and ignored published studies and a meta-analysis. On the contrary, we explicitly distinguish between these two phases of care and even abbreviate them, so as to clarify our position throughout. Unfortunately, the definition of opioid-free anesthesia in literature seems to be loosely applied and consequentially misinterpreted. Whether opioid-free anesthesia means total abstinence or relative lack of intraoperative opioids is unclear. We discuss this as an important limitation of the review and meta-analysis by Frauenknecht et al., in which included studies used opioids during the intraoperative period, thereby resulting in a potentially inappropriate conclusion. Furthermore, our...

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