The interpretation of blood lactate results, especially with respect to elevated values, is often based on inaccurate assumptions. We decided upon this topic for the Clinical Focus Review based on our observations of clinicians from all disciplines who routinely gave fluid boluses to normalize the lactate of patients with hemodynamic stability, euvolemia, and normal acid base balances without ruling out the reason for the hyperlactatemia.

We are in agreement with Woehlck et al. that lactate can be elevated from stored red blood cells as well as the inability to clear during massive transfusions. The studies of lactate metabolism in adipocytes were biochemically complex, extensive, and data-rich. However, we feel that the applicability of in vitro rat cell results and studies of Drosophila to humans is too premature.

The comments of Bahlmann and Werner-Moller4...

You do not currently have access to this content.