We thank Lacomis et al. for their interest in our study published in Anesthesiology, and we appreciate the opportunity to respond to their comments.

Their first question is whether the finding that the increased concentration of interleukin-6 in the blood at 1 h after surgical incision may be predictive of delayed neurocognitive recovery on postoperative days 5 to 7 is a true phenomenon. It is known that one can find false-positive results/relationships if multiple comparisons are performed on many sets of data. This issue is applicable to numerous situations including the data generated by conventional methods, such as our study, and by bioinformatics approaches. One method to reduce the possibility of false positive findings is to use an appropriate statistical method. In our case, the serum concentrations of 14 biomarkers including interleukin-6 were...

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