We thank Drs. Xiong et al.1 and Carella and Bonhomme2 for their comments regarding the shaping anesthetic techniques to reduce post-operative delirium (SHARP) study.3 We agree that evaluating intraoperative hypotension as a potentially moderating factor in the SHARP trial would be interesting. We found no difference in the number of minutes at a mean arterial pressure less than 55 mmHg between the spinal anesthesia with targeted sedation group (median, 0 min; interquartile range, 0 to 5) and the general anesthesia group (median, 0 min; interquartile range, 0 to 5; P = 0.51). Further, when the number of minutes at a mean arterial pressure less than 55 mmHg (considered as a categorical variable) was added to the main regression model as an interaction term, the interaction term was not significant, indicating that mean arterial pressure less than 55 mmHg did not modify the effect of anesthetic choice...
Targeting Depth of Anesthesia to Prevent Delirium: Reply
(Accepted for publication March 3, 2022. Published online first on April 7, 2022.)
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Charles H. Brown, Charles W. Hogue; Targeting Depth of Anesthesia to Prevent Delirium: Reply. Anesthesiology 2022; 136:1047–1048 doi: https://doi.org/10.1097/ALN.0000000000004197
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