Transfusions in Lung Transplantation: Reply

First, we would like to thank Strauss et al.¹  for their insight regarding the problem of primary graft dysfunction in response to our recent clinical review article.² 

This article correctly points out that primary graft dysfunction, or perioperative allograft injury due to ischemia or reperfusion injury, is a significant problem after lung transplantation and is multifactorial. In 2017, the International Society for Heart and Lung Transplantation (Chicago, Illinois) published the clinical definition of primary graft dysfunction, which created a consensus for diagnosis, that can be consistently measured across centers at specific time points, and quantified severity.³  We appreciate Strauss et al. highlighting the other contributing factors to primary graft dysfunction, which include the disruption of the endothelial-epithelial alveolar membrane of the new allograft and the direct result of ischemia-reperfusion injury. Primary graft dysfunction is a diagnosis that well characterizes the clinical injury to the new allograft, with...