We are more than happy to answer the questions Schulthess et al. have, based on our previous publication. The first question was to provide baseline characteristics of patients with and without myocardial injury. Their second question was related to the exposure and the associated risk for myocardial injury. Schulthess et al. are correct that duration under a mean arterial pressure (MAP) threshold of 75 mmHg is only associated with myocardial injury for prolonged periods of time. To graphically represent the relation between length of hypotension and myocardial injury, we could have chosen a MAP target of 60 mmHg where all durations, above 1 h, show an increased risk for myocardial injury. However, we have specifically chosen to report the highest threshold because this threshold was selected based on the figure in the supplemental digital content...

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