It was a pleasure to read the article from Verret et al. in a recent issue of Anesthesiology. The main prerequisites of a high-quality systematic review were met; however, some considerations about the patient, intervention, comparison, and study design approach applied and the conclusion of the review must be addressed. The main outcomes of the meta-analysis pooled results of highly divergent procedures, from endoscopic procedures to major surgeries. A relevant issue in both the Enhanced Recovery after Surgery and the Perioperative Surgical Home doctrines is the specificity of surgical route standardization.2,3  The possibility of another analgesic regiment being used in the comparator group is another concern. The use of gabapentin was compared with antidepressants, opioids, ketamine, nonsteroidal anti-inflammatory drugs, corticosteroids, benzodiazepines, neuroleptics, anticonvulsant, α2-adrenergic receptor agonists, paracetamol, melatonin, and placebo....

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