We thank Dr. Araujo for his interest on our systematic review about the perioperative use of gabapentinoids for the management of postoperative acute pain. The main purpose of a systematic review with meta-analyses is to synthesize treatment effects considering all available data. By pooling data from different trials, the power to detect a differential effect is increased. Trials included in a systematic review frequently present some degree of clinical heterogeneity. However, not considering these trials in pooled analyses, as suggested by Dr. Araujo, would diminish our collective ability to both answer important research questions and understand the modifiers of important treatment effects.

In our systematic review, we carefully considered potential sources of clinical heterogeneity among the included trials. First, we performed subgroup analyses to explore whether clinical heterogeneity or methodologic aspects of included trials could...

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