We read the article “Volatile versus Total Intravenous Anesthesia for Cancer Prognosis in Patients Having Digestive Cancer Surgery” by Makito et al. with great interest. This study is a large clinical retrospective study of more than 190,000 surgical patients with cancer. For further statistical analysis, the authors did a score-matching analysis to compensate for the huge difference in the number of patients who received volatile or intravenous anesthesia. They concluded that there were no significant differences between anesthetic choices on cancer recurrence/survival after surgery. However, we found several limitations in this study which may distort the data analysis. First, various cancer types and surgeries were included in the same analysis; however, it is well known that cancer aggressiveness and malignancy largely differ between cancer types and their origins. Second, the subgroup analysis for each type...

You do not currently have access to this content.