In a laudable effort, Vasilopoulos et al. studied the early postoperative pain trajectories from a mixed surgical population with the aim to improve prediction of pain responses, thereby serving as a basis for a future personalized analgesic approach to optimize recovery. The study included a detailed preoperative assessment of relevant patient characteristics and intraoperative use of anesthetic and analgesic interventions subsequently analyzed with relevant multiple statistical methods.

As presented, this is one of the few studies to cover this important topic, but it is surprising that despite the detailed pre- and intraoperative data, there is no detailed information about postoperative pain treatment for the primary 0 to 7 days postoperative pain outcome. Neither does it seem to be included in the analysis of the postoperative pain trajectory.

Consequently, because of the lack of...

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