I write to offer a comment and a suggestion on the systematic review and meta-analysis by Hussain et al. of local anesthetics used for fascial plane block.1 This report compared analgesia between liposomal bupivacaine and plain bupivacaine, the primary outcome being rest pain scores over the 24-to-72 h postoperative interval expressed as an area under the curve.1 Using data from 874 patients in 13 studies and adopting a Hartung-Knapp-Sidik-Johnkman random-effects model with the pain severity difference between treatments transformed as a standardized mean difference, the authors report in the abstract and the body that “No difference was observed between the two groups for area under the curve scores, with a standardized mean difference (95% CI) of –0.21 cm.h (–0.43 to 0.01; P = 0.058; I2 = 48%).” The authors used excellent statistical methods and software within frequentist statistical methodology; inferences were made by null hypothesis significance testing....
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Letter to the Editor|
November 2024
Liposomal Bupivacaine for Fascial Plane Block: Comment
Nathan L. Pace, M.D., M.Stat.
Nathan L. Pace, M.D., M.Stat.
University of Utah, Salt Lake City, Utah. n.l.pace@utah.edu
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Accepted for publication October 9, 2024.
Anesthesiology Newly Published on November 2024. doi:
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Nathan L. Pace; Liposomal Bupivacaine for Fascial Plane Block: Comment. Anesthesiology Newly Published on November 13, 2024. doi: https://doi.org/10.1097/ALN.0000000000005260
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