A146 ROUTINE APPLICATION OF HIGH-DOSE APROTININ IN OPEN-HEART SURGERY- A STUDY ON 1,784 PATIENTS

Inst. for Anesthesiology, German Heart Center Munich, FRG The application of the proteinase inhibitor aprotinin may considerably reduce bleeding in open-heart surgery (1–4). To study the clinical effectiveness and safety of aprotinin we evaluated the data of 1,784 consecutive patients with and without aprotinin treatment prospectively.