We thank Introna et al. 1for their kind comments regarding our manuscript. 2The authors correctly point out that a comprehensive approach to assessing the autonomic nervous system effects of anesthetic and sedative drugs provides clinically useful insight into their cardiovascular effects. Measurement of variations in systolic blood pressure is a well-characterized method for measuring peripheral sympathetic nervous system responses to various autonomic stressors, and such data might have furthered our findings. 2,3We chose, however, to focus on the cardiac autonomic effects of sedative doses of dexmedetomidine during clinically common thermal stress. Future investigation along these lines that incorporate measurement of systolic blood pressure variations might prove to be useful.