Women respond differently to anesthesia than men, initially recovering more rapidly, but having more postoperative morbidity. Studies on surgical patients report evidence of memory formation during anesthesia. However, sex differences in memory formation have not been explored. Therefore, the authors investigated sex differences in the implicit and explicit memory formation during general anesthesia.


With ethics committee approval, 120 consenting adult patients scheduled to undergo surgery during general anesthesia were recruited. Intraoperatively, 16 target words were presented to patients via headphones, and the Bispectral Index was recorded. Postoperatively, memory for presented words was tested using a word stem completion test. The test was divided into inclusion and exclusion parts, to delineate implicit and explicit memory contributions.


Target and distracter hit rates were similar in men and women. For the whole study group, there was a significant difference between inclusion target hit rate (0.42) and base hit rate (0.39) (P = 0.01). Buchner's model suggested that this memory formation was attributable to both implicit and explicit memory. A Bispectral Index value greater than 50 was the only significant predictor of inclusion target hit rate. None of the patients were able to consciously recall the words presented during surgery.


Patients showed greater memory performance for words presented during general anesthesia than for words not presented. However, sex differences in memory formation were not observed. A relation between hypnotic state and memory during sevoflurane anesthesia was also established, suggesting that memory formation is possible even at hypnotic depths considered to be adequate anesthesia.

WHETHER patients may form unconscious memories during anesthesia, and whether these memories matter, is an intriguing subject.1,2Older studies on this subject were confounded by methodologic problems, including inability to correlate memory with depth of anesthesia because of inadequate depth of anesthesia monitoring, and inability to eliminate the influence of active recall when testing for unconscious memory.3,4Recent studies have used Bispectral Index (BIS) monitoring and a sophisticated memory-testing technique called the Process Dissociation Procedure5to overcome these problems.6–15These studies report that memories can be formed unconsciously during apparently adequate anesthesia, but only if anesthesia is relatively light6–8,11,15and word presentation occurs during surgery.10,12,13However, these factors explain only part of the variability between patients with respect to unconscious memory formation, and more predictive factors must be sought.1,2 

Women recover more rapidly from anesthesia than men.16–24This phenomenon has not been fully explained but may mean that women regain cognitive function more rapidly than men if anesthetic depth lightens during surgery. Indeed, women are more likely to report awareness25–29and dreaming30–32during anesthesia than men, but whether women form more unconscious memories during anesthesia than men is not known. We therefore tested the hypothesis that women have a greater hit rate than men for target words in a word stem completion (WSC) test administered during a standardized BIS-titrated anesthetic. We also explored the contribution of explicit and implicit memory to general memory performance using the Process Dissociation Paradigm and determined the relation between memory formation and the depth of anesthesia as determined by BIS in our patients.

Materials and Methods

With the approval of the Human Research Ethics Committee of the Royal Melbourne Hospital (Parkville, Victoria, Australia) and written informed consent, 120 patients aged 18–75 yr, with American Society of Anesthesiologists’ physical status I–III, and presenting for elective surgery during relaxant general anesthesia were studied. All participants were native English speakers or fluent in English as their second language. Exclusion criteria included (1) intracranial, aural, and cardiothoracic surgery; (2) deafness; (3) memory disturbance or intellectual disability; (4) plan for benzodiazepine premedication; and (5) not expected to be available for, nor able to cooperate with, the postoperative interview.

Word Stem Completion Test

We used the WSC test (a commonly used perceptual priming task6,7,11–15) to measure memory performance. In the WSC test, the patient is primed by exposure to a target word during anesthesia. After recovery from anesthesia, the patient is presented with the first part of a word (word stem) and is asked to complete it. Completion of a word stem with a target word presented during surgery is termed a “hit.” An increased hit rate over the base rate without priming is evidence of memory formation.

Thirty-two five-letter words with a base hit rate of approximately 0.30 were selected from a list compiled by us in Australian patients.33Each target word was recorded digitally by the same female investigator and then edited with Cool Edit 2000 1.1 (Syntrillium Software Corporation, Phoenix, AZ), so that only the first three letters were enounced and a word stem was derived. Audio compact disks were created containing a short greeting and complete words, repeated 40 times each for presentation during anesthesia, and the appropriate words stems for presentation postoperatively.

Based on a previous study by Lubke et al. ,7who demonstrated learning (hits = 6.9 words out of 16) over base rates (hits = 4.8 words out of 16) in women undergoing cesarean delivery during general anesthesia, we planned to recruit 60 male and 60 female patients (α= 0.05; β= 0.2; SD = 2.0). Patients underwent block randomization by sex to one of four groups (n = 30 per group). Each group contained 15 men and 15 women. Two lists of target words and two lists of distracter words were allocated to each group (table 1). Ten compact discs were created for each group with target words and word stems randomized in order on each compact disc, and these were allocated randomly to each patient in the group. Each compact disc was used three times. The word presentation lasted approximately 42 min. Patients and postoperative observers were blind to the allocation of the word lists.

Table 1. Word List Presentation Scheme 

Table 1. Word List Presentation Scheme 
Table 1. Word List Presentation Scheme 


Before induction of anesthesia, patients were asked to adjust headphone volume and position for maximum comfort. Routine monitoring and BIS monitoring (BIS-XP® version 4.0; Aspect Medical Systems, Inc., Newton, MA) were commenced. Anesthesia was induced with fentanyl, propofol, and a nondepolarizing muscle relaxant and maintained with sevoflurane in oxygen–air. The trachea was intubated, and intermittent positive-pressure ventilation was commenced via  a circle circuit. Anesthesiologists were asked to titrate the inspired concentration of sevoflurane in a BIS range of 55–60 during word presentation to ensure that subjects were standardized to the depth of hypnosis. Morphine and antiemetics were administered after word presentation, if indicated. After the first skin incision, the two lists of words were played to the patient via  a laptop computer that also recorded BIS values at 5-s intervals. At the end of surgery, neuromuscular blockade was reversed, the patient’s trachea was extubated, and he or she was transferred to the postanesthesia care unit.

Patients were assessed 4–24 h postoperatively when they recovered from the hypnotic effects of anesthesia (i.e. , were awake and orientated with pain and nausea adequately controlled). The WSC test was then administered. Instructions were provided before each part of the test. The word stems from all four lists were presented aurally via  headphones, maintaining the same context of presentation as during surgery. Patients were asked to write down their responses, or if necessary, the researcher helped to record their responses. We used the Process Dissociation Paradigm5to separate implicit and explicit learning. In the inclusion part, patients were asked to complete word stems with a word that they remembered hearing during anesthesia or the first word that came to mind (one list of target words and one list of distracters). In the exclusion part, patients were asked to complete word stems with a word they had not heard during anesthesia (one list of target words and one list of distracters). Implicit memory facilitates a higher hit rate in the inclusion and exclusion parts over the base rate, whereas explicit memory increases the inclusion hit rate but decreases the exclusion hit rate.

The following data were collected: demographics, preoperative quality-of-recovery scores (a validated nine-item questionnaire on quality of recovery with a minimum score of 0 and a maximum score of 18; collection of a preprocedure baseline score is also validated34) and hospital anxiety and depression scores (0–14 possible score for each of anxiety and depression35), times of induction of anesthesia, first surgical incision, completion of wound closure, tracheal extubation, first eye opening, and Aldrete score of greater than 9.36Before postoperative memory testing, patients were assessed for quality-of-recovery scores, hospital anxiety and depression scores, recall of anesthesia, and dreaming using a standardized questionnaire37: “What is the last thing you remember before you went to sleep?”“What is the first thing you remember when you woke up?”“Did you remember anything in between?” and “Did you have any dreams during anesthesia?”

Statistical Analyses

Statistical analyses were performed using Stata 8.2 (Stata Corporation, College Station, TX). Continuous variables were graphed to assess their distribution. Normally distributed variables were summarized using mean ± SD, skewed variables using median (range), and categorical variables using number (%). Comparisons were made using the Student t  test (normally distributed variables), the Wilcoxon rank sum test (skewed variables), or chi-square tests (categorical variables). Survival data (times to an event) were assessed using log-rank tests.

To assess the constancy of BIS values, we calculated the performance error (PE: bias), using the formula PE = ((BIS − mean BIS)/mean BIS) × 100, the absolute PE (inaccuracy), which is the absolute value of the PE and the wobble (intraindividual variability) using the formula wobble =|PE − median PE|.

The mean numbers of hits, and the hit probability for word stems that were attempted, were calculated for targets and distracters in the inclusion and exclusion parts of the test. The comparisons of interest were (1) inclusion target hit rate versus  inclusion distracter hit rate (testing general memory performance) and (2) exclusion target hit rate versus  exclusion distracter hit rate (testing explicit memory performance). These comparisons were made using paired, two-tailed t  tests. Figure 1shows the Buchner multinomial processing model,38which was used to estimate explicit and implicit memory probabilities from the hit frequencies for targets and distracters in the inclusion and exclusion tests.

Fig. 1. Buchner  et al. 38,multinomial processing model of memory.  e represents explicit memory,  i represents implicit memory, and  g and  h are the base rate parameters in the inclusion and exclusion parts, respectively. From Lubke  et al. 6; reproduced with permission. 

Fig. 1. Buchner  et al. 38,multinomial processing model of memory.  e represents explicit memory,  i represents implicit memory, and  g and  h are the base rate parameters in the inclusion and exclusion parts, respectively. From Lubke  et al. 6; reproduced with permission. 

Bispectral Index values were categorized (≤ 40, 40.1–45, 45.1–50, 50.1–55, 55.1–60, > 60) on the basis that the range 40–60 is considered appropriate for general anesthesia.39By definition, distracters were not presented during surgery and therefore had no corresponding BIS value, so for all BIS categories, matching distracter frequencies were calculated from base rate performance (i.e. , 0.38) and the number of words presented. We addressed whether general memory performance was significant at BIS values greater than or less than 50, on the basis that (1) it represents the midpoint of the recommended range; (2) learning seems more likely with BIS values above 50;6and (3) there have been previous reports of wakefulness40and awareness28in the 50–60 range or below.41Chi-square analyses were used to compare hits/misses in the target/distracter groups at BIS values greater than or less than 50.

Univariate logistic regression was used to determine predictors of general memory performance (as determined by the hit rate on the inclusion target words that were attempted). Prospectively defined predictors included age, sex, preoperative hospital anxiety and depression score, mean BIS value greater than 50 during word presentation, duration of anesthesia, time to eye opening, time to WSC test, and report of dreaming. Continuous variables were categorized based on visual inspection of graphs versus  hit rate. Predictors with P  values less than 0.2 were included in a multivariate logistic regression model.


Recruitment to the trial is outlined in figure 2. Six men and one woman received midazolam before induction despite its exclusion from the protocol and were removed from the analyses. The 52 men and 61 women remaining were aged 48 ± 15 and 45 ± 15 yr (P = 0.32), weighed 86 ± 15 and 76 ± 18 kg (P = 0.002), and had mainly American Society of Anesthesiologists physical status I or II (79% and 82%; P = 0.96), respectively. Mean BIS values were similar in men and women during word presentation but were lower than suggested by the protocol (table 2). The median of the median PEs during word presentation was 0% (range, −18% to 8%), and the median of the median absolute PEs was 8% (1% to 24%). The median of the median wobbles was 7% (0% to 24%), i.e. , the typical patient’s BIS value varied by 3 BIS units during the word presentation, and the worst patient’s BIS varied by 14 BIS units.

Fig. 2. Trial profile. WSC = word stem completion test 

Fig. 2. Trial profile. WSC = word stem completion test 

Table 2. Perioperative Data 

Table 2. Perioperative Data 
Table 2. Perioperative Data 

Follow-up interviews were conducted on men and women 16.1 (1.5–24) and 17.4 (3.8–24) hours postoperatively (P = 0.23). Postoperative quality-of-recovery scores were significantly lower than preoperative scores in men (P = 0.003) and women (P < 0.001). No significant differences in hospital anxiety and depression scores were observed in either men or women (P = 0.33 and P = 0.43, respectively). The prevalence of dreaming among interviewed patients was 11% (men 10% and women 12%; P = 0.68). None of the patients were able to consciously recall the words presented during surgery. One woman undergoing a laparoscopic cholecystectomy recalled a short episode involving a tugging sensation in the right upper quadrant of her abdomen and being unable to move. She did not recall hearing the word presentation. The recorded BIS data showed several 1- to 2-min periods of BIS values between 60 and 63. She was interviewed on several further occasions and was offered counseling, and there were no adverse sequelae.

The hit rates and frequencies were calculated based on the number of word stem completion attempts, because 119 presented stems (4%) were not completed. No differences were observed in hit rates between men and women in either of the four test conditions.

Target words were used to complete word stems significantly more often than distracter words in the inclusion part of the test (P = 0.01), but there was no significant difference between target and distracter hit rates in the exclusion part of the test (P = 0.30) (table 3). Although the observed base hit rate in the inclusion test (0.39) was higher and that in the exclusion test (0.24) was lower than 0.3 (the base rate as evidenced in our pilot study, which was conducted in a demographically similar cohort of patients33), these differences were not significant (P = 0.30 and P = 0.29, respectively).

Table 3. Word Stem Hit Rates 

Table 3. Word Stem Hit Rates 
Table 3. Word Stem Hit Rates 

The estimate for explicit memory from the Buchner model38was 0.038 (SE = 0.018 [95% confidence interval, 0.002–0.073]) and for implicit memory was 0.041 (SE = 0.019 [0.004–0.078]). The 95% confidence interval for both explicit and implicit memory estimations were exclusive of zero (i.e. , significant).

General memory performance was significantly higher than base rate performance at BIS values greater than 50 (P = 0.012). At BIS values of less than 50, general memory performance was not significantly different from base rate performance (P = 0.83). A BIS value greater than 50 was the only predictor of inclusion target hits (i.e. , improved general memory performance) in the logistic regression model (tables 4 and 5and fig. 3).

Fig. 3. Inclusion target hit rate (THR; mean [95% confidence intervals]) for words presented during sevoflurane anesthesia grouped according to Bispectral Index (BIS) values and compared with the observed base hit rate (BHR). 

Fig. 3. Inclusion target hit rate (THR; mean [95% confidence intervals]) for words presented during sevoflurane anesthesia grouped according to Bispectral Index (BIS) values and compared with the observed base hit rate (BHR). 

Table 4. Predictors of General Memory Performance 

Table 4. Predictors of General Memory Performance 
Table 4. Predictors of General Memory Performance 

Table 5. Bispectral Index Categorization of Inclusion Target Hits 

Table 5. Bispectral Index Categorization of Inclusion Target Hits 
Table 5. Bispectral Index Categorization of Inclusion Target Hits 


This study provides further evidence that memory formation may occur during apparently adequate general anesthesia.6–8,10–14However, we were unable to demonstrate a difference in memory formation between men and women. We conclude that men and women anesthetized to equivalent levels of hypnosis with sevoflurane are equally likely to form memories during anesthesia.

Target hit rates were higher than distracter hit rates in the inclusion part of our study, indicating improved general memory performance over baseline. In contrast, target and distracter hit rates in the exclusion part were similar, providing no evidence for explicit memory formation. However, exclusion target and distracter hit rates were lower than expected from the pilot study.33This may be because our patients completed fewer exclusion stems than inclusion stems and tended to use unusual words to complete the exclusion part of the test. By including data from both parts of the test in the Buchner model, we were able to differentiate the effects of implicit and explicit memory on general memory performance and detect both implicit memory and a weak form of explicit memory that allowed exclusion decisions to be made.

In addition, we were able to explore the relation between memory formation and anesthetic depth by matching BIS values to each word presentation. Our results suggest that the odds of memory formation are significantly increased at BIS values greater than 50. This is consistent with previous reports,6–8,11,14in particular the study of Lubke et al.  7in cesarean delivery patients. In that study, inclusion hit rates were significantly greater than, whereas exclusion hit rates were not different from, base rates, and the Buchner model revealed a form of explicit memory that allowed inclusion–exclusion decisions to be made in the absence of postoperative recall. The mean BIS value during word presentation was 76 ± 3. Similarly, Deeprose et al.  12,13reported implicit memory formation during surgery even when BIS values were lower (mean = 42). In contrast, Kerssens et al.  15were unable to demonstrate memory formation when mean BIS values during word presentation were 49 ± 6 (identical to our study). The rate of fluctuation in anesthetic depth during word presentation may be a crucial factor: 8% of words were presented as BIS values greater than 60 in our study, 11% in the study of Deeprose et al. ,13but only 1% in the study of Kerssens et al.  15Greater fluctuation in our study compared with that of Kerssens et al.  may have been due to our higher target BIS range of 55–60.

One woman in our study had an episode of awareness. Because she did not remember word presentation, it is possible that this episode occurred during a 10-min period toward the end of surgery when BIS values were around 60. No other signs of inadequate anesthesia were detected during the operation. This episode adds weight to an argument that episodes of BIS greater than 60 must be interpreted promptly along with other data and be acted upon if necessary.28Furthermore, we suggest that BIS values less than 50 (rather than less than 60) may be necessary to make awareness and unconscious memory formation a sufficiently remote possibility for our patients.

This study was designed to maximize our ability to demonstrate a difference between memory formation during anesthesia in men and women, if one existed: (1) We avoided the use of preoperative midazolam, because of its amnesic and anxiolytic effects15; (2) we chose sevoflurane (rather than propofol) for anesthetic maintenance15,42; (3) we standardized anesthetic depth at 55–603,4; (4) we presented words during (rather than before) surgery10,12,13; (5) we attempted to test patients as soon as they recovered from the hypnotic effects of anesthesia3,4; (6) we maintained the same (auditory) context during priming and testing3,4; and (7) we used the Process Dissociation Paradigm to distinguish between the contributions of implicit and explicit memory.6,7 

Several issues arise from our study design that require discussion. Firstly, six patients received midazolam despite its exclusion from the protocol. However, post hoc  analyses excluded an influence of midazolam on the primary endpoint. Secondly, a BIS target of 55–60, although likely to maximize memory formation in this context,6–8,11,15was not achieved in practice. Anesthesiologists encountered difficulty in titrating sevoflurane to maintain the BIS in this range, in the face of varying surgical stimulation, the lag between alterations in dialed concentration and effect, the lag in calculating the BIS, and concern about increased excursions of BIS values above 60.15The lower mean BIS values achieved in this study (men, 48; women, 49) may have minimized the difference between men and women in memory formation, because fewer patients may have had arousals during anesthesia that allowed memories to be formed.15Thirdly, we chose to interview patients between 4 and 24 h postoperatively. Because the effects of priming fade with time,3this may have minimized our estimate of learning, but not the difference between men and women. Although a response to priming may still be demonstrated after 48 h, as short a period as possible between priming and testing is preferable, although testing while residual hypnotic effects of anesthesia remain is undesirable.3 

Recovery times and the quality of recovery, as evidenced by quality of recovery and hospital anxiety and depression scores, were similar in men and women. Our results contrast with previous reports of more rapid awakening from anesthesia maintained with propofol or volatile anesthetics,16–24but poorer quality of recovery,34in women than in men. Recovery from anesthesia was defined as the time from cessation of sevoflurane to the time of first eye opening. However, administration of sevoflurane after the word presentation was completed was not done per protocol, so some patients may have received reducing concentrations of sevoflurane before cessation, whereas others may have been on constant concentrations. The amount of opioid analgesia also was not controlled. The pattern of drug administration could have been different in women and men, and this could have influenced this result. Alternatively, this study may have been underpowered to assess this secondary endpoint.

In conclusion, we demonstrated improved general memory performance after priming during general anesthesia with sevoflurane, but there was no difference between men and women. Memory formation was more likely at BIS values greater than 50. The clinical importance of implicit memory formation during anesthesia remains unknown, and further research is required to establish whether it has any untoward sequelae.1,2 


Veselis R: Gone but not forgotten—or was it? Br J Anaesth 2004; 92:161–3
Andrade J: Does memory priming during anesthesia matter? Anesthesiology 2005; 103:919–20
Andrade J: Learning during anaesthesia: A review. Br J Psych 1995; 86:479–506
Ghoneim M, Block R: Learning and memory during general anesthesia: An update. Anesthesiology 1997; 87:387–410
Jacoby L: A process dissociation framework: Separating automatic from intentional uses of memory. J Mem Lang 1991; 30:513–41
Lubke G, Kerssens C, Phaf H, Sebel P: Dependence of explicit and implicit memory on hypnotic state in trauma patients. Anesthesiology 1999; 90:70–80
Lubke G, Kerssens C, Gershon R, Sebel P: Memory formation during general anesthesia for emergency cesarean section. Anesthesiology 2000; 92:1029–34
Stapleton C, Andrade J: An investigation of learning during propofol sedation and anesthesia using the process dissociation procedure. Anesthesiology 2000; 93:1418–25
Kerssens C, Klein J, Van Der Woerd A, Bonke B: Auditory information processing during adequate propofol anesthesia monitored by electroencephalogram bispectral index. Anesth Analg 2001; 92:1210–4
Andrade J, Englert LCH, Edwards N: Comparing the effects of stimulation and propofol infusion rate on implicit and explicit memory formation. Br J Anaesth 2001; 86:189–95
Kerssens C, Lubke G, Klein J, Van der Woerd A, Bonke B: Memory function during propofol and alfentanil anesthesia. Anesthesiology 2002; 97:382–9
Deeprose C, Andrade J, Varma S, Edwards N: Unconscious learning during surgery with propofol anaesthesia. Br J Anaesth 2004; 92:171–7
Deeprose C, Andrade J, Harrison D, Edwards N: Unconscious auditory priming during surgery with propofol and nitrous oxide anaesthesia: A replication. Br J Anaesth 2005; 94:57–62
Iselin-Chaves I, Willems S, Jermann F, Forster A, Adam S, Van der Linden M: Investigation of implicit memory during isoflurane anesthesia for elective surgery using the process dissociation procedure. Anesthesiology 2005; 103:925–33
Kerssens C, Ouchi T, Sebel P: No evidence of memory formation during anesthesia with propofol or isoflurane with close control of hypnotic state. Anesthesiology 2005; 102:57–62
Apfelbaum J, Grasela T, Hug C, McLeskey C, Nahrwold M, Roizen J, Stanley T, Thisted R, Walawander C, White P: The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: Characteristics associated with prolonged time to awakening. Anesth Analg 1993; 77:S10–4
Gan T, Glass P, Sigl J, Sebel P, Rosow C: Women emerge from general anesthesia with propofol/alfentanil/nitrous oxide faster than men. Anesthesiology 1999; 90:1283–7
Hoymork S, Raeder J, Grimsmo B, Steen P: Bispectral Index, predicted and measured drug levels of target-controlled infusions of remifentanil and propofol during laparoscopic cholecystectomy and emergence. Acta Anaesthesiol Scand 2000; 44:1138–44
Myles P, Hunt J, Fletcher H: Sex differences in speed of emergence and quality of recovery after anaesthesia: A cohort study. BMJ 2001; 322:710–1
Ward D, Norton J, Guivarc’h P-H, Litman R, Bailey P: Pharmacodynamics and pharmacokinetics of propofol in a medium-chain triglyceride emulsion. Anesthesiology 2002; 97:1401–8
Hoymork S, Raeder J, Grimsmo B, Steen P: Bispectral index, serum drug concentrations and emergence associated with individually adjusted target-controlled infusions of remifentanil and propofol for laparoscopic surgery. Br J Anaesth 2003; 91:773–80
Kreuer S, Biedler A, Larsen R, Altmann S, Wilhelm W: Narcotrend monitoring allows faster emergence and a reduction of drug consumption in propofol–remifentanil anesthesia. Anesthesiology 2003; 99:34–41
Hoymork S, Raeder J: Why do women wake up faster than men from propofol anaesthesia? Br J Anaesth 2005; 95:627–33
Buchanan F, Myles P, Leslie K, Forbes A, Ciccuttini F: Gender and recovery after general anesthesia combined with neuromuscular blocking drugs. Anesth Analg 2006; 102:291–7
Ranta S, Ranta V, Aromaa U: The claims for compensation for awareness with recall during general anaesthesia in Finland. Acta Anaesthesiol Scand 1997; 41:356–9
Domino K, Posner K, Caplan R, Cheney F. Awareness during anesthesia: A closed claims analysis. Anesthesiology 1999; 90:1053–61
Sandin R, Enlund G, Samuelsson P, Lennmarken C: Awareness during anaesthesia: A prospective case study. Lancet 2000; 355:707–11
Myles P, Leslie K, McNeil J, Forbes A, Chan M: Bispectral index monitoring to prevent awareness during anaesthesia: The B-Aware randomised controlled trial. Lancet 2004; 363:1757–63
Sebel P, Bowdle T, Ghoneim M, Rampil I, Padilla R, Gan T, Domino K: The incidence of awareness during anesthesia: A multicenter United States study. Anesth Analg 2004; 99:833–9
Wilson S, Vaughan R, Stephen C: Awareness, dreams, and hallucinations associated with general anesthesia. Anesth Analg 1975; 54:609–17
Ranta S, Laurila R, Saario J, Ali-Melkkila T, Hynynen M: Awareness with recall during general anesthesia: Incidence and risk factors. Anesth Analg 1998; 86:1084–9
Leslie K, Myles P, Forbes A, Chan M, Swallow S, Short T: Dreaming during anaesthesia in patients at high risk of awareness. Anaesthesia 2005; 60:239–44
Lee L, Leslie K: Target words for the Word Stem Completion test in Australian patients. Anaesth Intensive Care 2003; 31:184–6
Myles P, Weitkamp B, Jones K, Melick J, Hensen S: Validity and reliability of a post-operative quality of recovery score: The QoR-40. Br J Anaesth 2000; 84:11–5
Zigmond A, Snaith R: The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67:361–70
Aldrete J, Kroulike D: A postanesthetic recovery score. Anesth Analg 1970; 49:924–34
Brice D, Hetherington R, Utting J: A simple study of awareness and dreaming during anaesthesia. Br J Anaesth 1970; 42:535–42
Buchner A, Erdfelder E, Vaterrodt-Plunnecke B: Toward unbiased measurement of conscious and unconscious memory processes within the process dissociation framework. J Exp Psychol Gen 1995; 124:137–60
Johansen J, Sebel P: Development and clinical application of electroencephalographic bispectrum monitoring. Anesthesiology 2000; 93:1336–44
Pemberton P, Dinsmore J: Bispectral index monitoring during awake craniotomy surgery. Anaesthesia 2002; 57:1244–5
Schneider G, Gelb A, Schmeller B, Tschakert R, Kochs E: Detection of awareness in surgical patients with EEG-based indices: Bispectral index and patient state index. Br J Anaesth 2003; 91:329–35
Glass PS, Bloom M, Kearse L, Rosow C, Sebel PS, Manberg P: Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane and alfentanil in healthy volunteers. Anesthesiology 1997; 86:836–47