A 61-YR-OLD man with renal cell carcinoma and inferior vena cava thrombus presented for nephrectomy with thrombectomy. Preoperative echocardiography was normal and excluded a patent foramen ovale.

During inferior vena cava dissection, the patient developed an acute decrease of end-tidal carbon dioxide and a loss of arterial pressure with waveform nonresponsive to cardiopulmonary resuscitation.

Emergency transesophageal echocardiographic examination revealed extensive thrombosis of the right heart chambers (right atrium [RA], right ventricle [RV]) and, unexpectedly, significant left ventricular (LV) and left atrial (LA) thrombus (fig. A). FigureB provides for comparison a normal transesophageal echocardiography four-chamber view from a different patient. The extensive thrombus observed in all four heart chambers explained the ineffectiveness of cardiopulmonary resuscitation efforts and excluded cardiopulmonary bypass as a viable alternative.

Figure. No caption available.

Figure. No caption available.

Renal cell carcinoma is associated with a hypercoagulable state, which results in inferior vena cava thrombosis in 4–10% of cases.1The etiology of this devastating intracardiac thrombosis involving left heart chambers remains elusive. Potential causes include a generalized thrombotic event secondary to a massive pulmonary embolism with a resultant low flow state in a hypercoagulable patient, or a right-to-left heart thrombus migration through a previously occult patent foramen ovale under the condition of increased right atrial pressures.

As illustrated, resection of renal cell carcinoma with inferior vena cava thrombosis can be complicated by tumor or thrombus dislodgment and cardiovascular collapse. Transesophageal echocardiography is indicated in such cases for confirming the diagnosis, allowing detection of thrombus migration, monitoring the effectiveness of resuscitation, and assisting surgical management.2,3 


Wotkowicz C, Wszolek MF, Libertino JA: Resection of renal tumors invading the vena cava. Urol Clin North Am 2008; 35:657–71
Komanapalli CB, Tripathy U, Sokoloff M, Daneshmand S, Das A, Slater MS: Intraoperative renal cell carcinoma tumor embolization to the right atrium: Incidental diagnosis by transesophageal echocardiography. Anesth Analg 2006; 102:378–9
Chen H, Ng V, Kane CJ, Russell IA: The role of transesophageal echocardiography in rapid diagnosis and treatment of migratory tumor embolus. Anesth Analg 2004; 99:357–9