ON THE COVER:
Awakening from anesthesia is not just about drug dissipation. In this issue, Chemali et al. show in animals that the monoamine transport inhibitor methylphenidate arouses animals anesthetized with propofol. This finding highlights the need for future studies designed to understand how propofol blocks sensory input (red arrow ) and suppresses the widely distributed brain mechanisms (gears ) regulating arousal.
Kelz and Sleigh: From the Edge of Oblivion: The Dance between Intrinsic Neuronal Currents and Neuronal Connectivity, p. 977
Chemali et al. : Active Emergence from Propofol General Anesthesia Is Induced by Methylphenidate, p. 998
