In the article on page 147 of the January 2012 issue, in the Conclusions section of the Abstract, the word “glycinexylidide” appeared instead of “N-ethylglycine” in two places. The Conclusions section of the Abstract should read as follows:
Conclusions: Although lidocaine does not function directly on GlyT1, its metabolites MEGX and N-ethylglycine were shown to inhibit GlyT1-mediated glycine uptake by at least two different mechanisms. Whereas N-ethylglycine was demonstrated to be an alternative GlyT1 substrate, MEGX was shown to inhibit GlyT1 activity in both primary astrocytes and in GlyT1-expressing Xenopus laevis oocytes at clinically relevant concentrations. These findings provide new insights into the possible mechanisms for the antinociceptive effect of systemic lidocaine.
The publisher regrets this error.
