Recently, spinal cord stimulation with higher frequency than in the past has been applied for treatment of chronic pain. Laboratory work in this issue shows different mechanisms and time course of effects with these higher frequencies.

  • Clark: Spinal Cord Stimulation: Does Frequency Matter?, p. 243

  • Shechter et al.: Conventional and Kilohertz-frequency Spinal Cord Stimulation Produces Intensity- and Frequency-dependent Inhibition of Mechanical Hypersensitivity in a Rat Model of Neuropathic Pain, p. 422