Translating experimenta findings in rodents to new treatment for pain in people is difficult. In this issue we highlight a new and promising translational development—treating clinical pain in our pets to improve their care while helping develop treatment for their owners.

  • Hayashida: Substance P-Saporin for Bone Cancer Pain in Dogs: Can Man’s Best Friend Solve the Lost in Translation Problem in Analgesic Development?, p. 999

  • Wiese et al.: Intrathecal Substance P-Saporin in the Dog: Distribution, Safety, and Spinal Neurokinin-1 Receptor Ablation, p. 1163

  • Brown and Agnello: Intrathecal Substance P-Saporin in the Dog: Efficacy in Bone Cancer Pain, p. 1178