This issue of Anesthesiology features a number of articles from the field of pediatric anesthesiology. Topics include examining the neurodevelopment effects of early childhood anesthesia exposure, regional anesthesia for cleft palate repair, preoperative sedation and emergence agitation, transthoracic ultrasound for assessing atelectasis in children, and airway management in a child with a giant encephalocele. (Photo Illustration by A. Johnson, Vivo Visuals; Images by Thinkstock [infant] and J.P. Rathmell [pediatric anesthesiologists].)