On The Cover:
Ketamine, used for more than 60 yr as a sedative, analgesic, and anesthetic, is now being explored as a rapidly acting antidepressant. An article in this month’s issue highlights the metabolites which may be responsible for this rapid antidepressant effect. (Illustration by A. Johnson, Vivo Visuals.)
van Velzen and Dahan: Ketamine Metabolomics in the Treatment of Major Depression, p. 4
Paul et al.: (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function, p. 149
Copyright © 2014, the American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins.