Loss of behavioral responsiveness (LOBR) is often used to define anesthesia-induced loss of consciousness. In this issue of Anesthesiology, Warnaby and her colleagues used electroencephalography and functional magnetic resonance imaging in healthy volunteers to identify changes in neural processing during ultraslow induction of anesthesia with propofol. The results suggest that the dorsal anterior insula cortex could be a key cortical region that underpins LOBR during induction of anesthesia. In an accompanying Editorial View, Mashour discusses how these findings inform us about the neurobiology of consciousness.

  • Warnaby et al.: Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response, p. 766

  • Mashour: Anesthetizing the Self: The Neurobiology of Humbug, p. 747