Blood transfusions are associated with morbidity and mortality. However, restrictive thresholds could harm patients less able to tolerate anemia. In this issue of Anesthesiology, Hovaguimian and Myles present the results of a systematic review to quantify the effects of transfusion strategies, concluding that restrictive transfusion strategies should be applied with caution in high-risk patients undergoing major surgery.

  • Hovaguimian and Myles: Restrictive versus Liberal Transfusion Strategy in the Perioperative and Acute Care Setting: A Context-specific Systematic Review and Meta-analysis of Randomized Controlled Trials, p. 46

  • Beattie and Wijeysundera: Approaching a Safe Last Resort: Triggers for Perioperative Blood Transfusion, p. 11