![In his 1914 masterwork Anoci-Association, Cleveland surgeon George W. Crile, M.D. (1864 to 1943), depicted (top) the “Moynihan Syringe for the Infiltration of Quinin[e] and Urea Hydrochlorid[e].” His book was published seven years after the first publication about long-lasting local anesthesia and analgesia following injection of a mixture of quinine with urea. Manufactured by Eli Lilly & Company of Indianapolis, the glass tube (bottom) contained “20 soluble hypodermic tablets” with 2 grains or 0.13 grams of Quinine-Urea mixture. Although it was a long-acting local anesthetic and analgesic, the quinine-urea mixture could delay wound healing if directly injected into wound edges. And that is why Dr. Crile recommended use of a syringe with a long offset needle such as Moynihan’s for infiltrating “at a Distance from the Incision.” (Copyright © the American Society of Anesthesiologists’ Wood Library-Museum of Anesthesiology.)](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/125/6/10.1097_aln.0000000000001424/3/m_22ff01.jpeg?Expires=1687485385&Signature=hZJKZzXPToyNS1Zbo4QlVgh3avGo1p7dEBvfH4deXm43Nk9R~E46C6XfuTn4Lqs~O5AkYbzDFJN60aD~6PcyH6gCEHJHoceqGy4T8CIUgkxRNQ3JSyTD~wXLvaAx5dEph0sk6kb99WlxlEMaW6qEVJhpGxYb7HyYz0Fz91BbDSXSQMZUq6uw~RnT8y0gq7STf70yobKo7L4a6OOgVypp71SaGX34hXFsHb4TfeM2RJNzaPvBhfWvtWd0WynqEhT8AxOuytQddREh9BoVlCcvwyORZdD4KUeRA9KBClIIrN7HgkVCPXceGedXVvrrU5L0adn71QzFak5EPocscsFZrw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
In his 1914 masterwork Anoci-Association, Cleveland surgeon George W. Crile, M.D. (1864 to 1943), depicted (top) the “Moynihan Syringe for the Infiltration of Quinin[e] and Urea Hydrochlorid[e].” His book was published seven years after the first publication about long-lasting local anesthesia and analgesia following injection of a mixture of quinine with urea. Manufactured by Eli Lilly & Company of Indianapolis, the glass tube (bottom) contained “20 soluble hypodermic tablets” with 2 grains or 0.13 grams of Quinine-Urea mixture. Although it was a long-acting local anesthetic and analgesic, the quinine-urea mixture could delay wound healing if directly injected into wound edges. And that is why Dr. Crile recommended use of a syringe with a long offset needle such as Moynihan’s for infiltrating “at a Distance from the Incision.” (Copyright © the American Society of Anesthesiologists’ Wood Library-Museum of Anesthesiology.)
In his 1914 masterwork Anoci-Association, Cleveland surgeon George W. Crile, M.D. (1864 to 1943), depicted (top) the “Moynihan Syringe for the Infiltration of Quinin[e] and Urea Hydrochlorid[e].” His book was published seven years after the first publication about long-lasting local anesthesia and analgesia following injection of a mixture of quinine with urea. Manufactured by Eli Lilly & Company of Indianapolis, the glass tube (bottom) contained “20 soluble hypodermic tablets” with 2 grains or 0.13 grams of Quinine-Urea mixture. Although it was a long-acting local anesthetic and analgesic, the quinine-urea mixture could delay wound healing if directly injected into wound edges. And that is why Dr. Crile recommended use of a syringe with a long offset needle such as Moynihan’s for infiltrating “at a Distance from the Incision.” (Copyright © the American Society of Anesthesiologists’ Wood Library-Museum of Anesthesiology.)
George S. Bause, M.D., M.P.H., Honorary Curator, ASA’s Wood Library-Museum of Anesthesiology, Schaumburg, Illinois, and Clinical Associate Professor, Case Western Reserve University, Cleveland, Ohio. UJYC@aol.com.
