Many modalities including peripheral nerve block, periarticular infiltration, and epidural analgesia have been used to provide analgesia after total knee arthroplasty, but their relative efficacy remains unknown. In this issue of Anesthesiology, Terkawi et al. conducted a network meta-analysis of 170 trials (12,530 patients) assessing 17 treatment modalities and concluded that blocking multiple nerves was preferable to blocking any single nerve, periarticular infiltration, or epidural analgesia. In an accompanying Editorial View, Ilfeld and McCartney discuss the importance of looking beyond pain scores and analgesic consumption to consider the priorities of all stakeholders when choosing among available options for providing analgesia after surgery.

  • Terkawi et al.: Pain Management Modalities after Total Knee Arthroplasty: A Network Meta-analysis of 170 Randomized Controlled Trials, p. 923

  • Ilfeld and McCartney: Searching for the Optimal Pain Management Technique after Knee Arthroplasty: Analgesia Is Just the Tip of the Iceberg, p. 768