Differentiating drug-related and state-related changes on electroencephalography during anesthetic-induced unconsciousness has remained difficult. In this issue of Anesthesiology, Scheinin et al. demonstrate that the electroencephalogram effects of dexmedetomidine and propofol are strongly drug- and state-dependent in 47 healthy participants. Changes in slowwave and alpha activity best detected different states of consciousness. Illustration by Sara Jarret, C.M.I.

  • Scheinin et al.: Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram, p. 22