To the Editor:

We thank Drs. Kharasch and Houle1  for commenting on an article2  and an editorial3  published in Anaesthesia in their Editorial Views. It would be more usual for questions to be posed to the authors of a journal article by means of correspondence to the primary journal, and we are sure that Drs. Carlisle, Loadsman, and McCulloch would be delighted to respond to any such letters. We would therefore refer the readers of Anesthesiology to such correspondence in Anaesthesia for further discussion of these articles and the issues arising.

In response to the specific suggestions made about the editorial policy of Anaesthesia, the Journal stands by its decision (and is supported in doing so by the Editorial Board) to screen all submitted randomized controlled trials for data distribution.4  However, we would like to point out that no article has ever been, or will ever be, rejected based on this screening alone5 ; a finding that a submission appears to have an unusual distribution of data is always followed by a request to the authors for original trial data,6 and it is the analysis of these data, along with the authors’ responses to further questioning, that leads to any decision to accept or reject. Many submissions initially flagged using this screening method are found to have done so through authors’ errors rather than intentional deception or worse.

Anaesthesia and its Editorial Board also stand by the suggestion that extreme distributions of baseline data merit further investigation, the expectation being that many, if not most, will turn out to be due to errors. The scientific record must be reliable, and Anaesthesia is happy to take the lead in checking past, as well as current/future, publications.

Competing Interests

Dr. Klein is current Editor-in-Chief of Anaesthesia. Dr. Yentis is the Immediate Past Editor-in-Chief of Anaesthesia. Dr. Clyburn is Chair of the Editorial Board of Anaesthesia and President of the Association of Anaesthetists of Great Britain and Ireland (London, United Kingdom).

References

1.
Kharasch
ED
,
Houle
TT
:
Errors and integrity in seeking and reporting apparent research misconduct.
Anesthesiology
2017
;
127
:
733
7
2.
Carlisle
JB
:
Data fabrication and other reasons for non-random sampling in 5087 randomised, controlled trials in anaesthetic and general medical journals.
Anaesthesia
2017
;
72
:
944
52
3.
Loadsman
JA
,
McCulloch
TJ
:
Widening the search for suspect data: Is the flood of retractions about to become a tsunami?
Anaesthesia
2017
;
72
:
931
5
4.
Klein
AA
:
What Anaesthesia is doing to combat scientific misconduct and investigate data fabrication and falsification.
Anaesthesia
2017
;
72
:
3
4
5.
Carlisle
JB
,
Dexter
F
,
Pandit
JJ
,
Shafer
SL
,
Yentis
SM
:
Calculating the probability of random sampling for continuous variables in submitted or published randomised controlled trials.
Anaesthesia
2015
;
70
:
848
58
6.
Carlisle
JB
:
The analysis of 168 randomised controlled trials to test data integrity.
Anaesthesia
2012
;
67
:
521
37