Both saline and lactated Ringer’s solution are commonly given to surgical patients. However, hyperchloremic acidosis consequent to saline administration may provoke complications. In this issue of Anesthesiology, Maheshwari et al. tested the primary hypothesis that a composite of in-hospital mortality and major postoperative complications is less common in patients given lactated Ringer’s solution rather than normal saline. In an accompanying editorial, Story places this new trial into perspective and warns against the generalizability to frail patients and those requiring large volumes of intravenous fluids. Cover illustration: S. Jarret, M.F.A., C.M.I. Cover photo: J. P. Rathmell.

  • Maheshwari et al.: Saline versus Lactated Ringer’s Solution: The Saline or Lactated Ringer’s (SOLAR) Trial, p. 614

  • Story: Intravenous Fluids: Which Recipe? p. 609