Gaining a better understanding of postoperative pain trajectories may impact acute postoperative suffering and lead to preventative therapies for persistent postsurgical pain. In this issue of Anesthesiology, Vasilopoulos et al. evaluated patterns of acute postoperative pain in a mixed surgical patient cohort and found multiple distinct pain intensity trajectories. In an accompanying editorial, Schreiber and Muehlschlegel review the recent evolution of postoperative pain measurement and call for personalization of pain treatment to an individual’s expected pain trajectory rather than the current protocolization based solely on the procedure being performed. Cover Illustration: A. Johnson, Vivo Visuals.

  • Vasilopoulos et al.: Patient and Procedural Determinants of Postoperative Pain Trajectories, p. 421

  • Schreiber and Muehlschlegel: Personalization over Protocolization: Embracing Diversity of Pain Trajectories after Surgery, p. 363