The relationship between late clinical outcomes after injury and early dynamic changes between fibrinolytic states is not fully understood. In this issue of Anesthesiology, Rossetto et al. examine temporal transitions in fibrinolysis states using rotational thromboelastometry (ROTEM) in a cohort of trauma patients. In an accompanying editorial, Myles and Medcalf discuss how this article advances our understanding of fibrinolysis and trauma outcomes. Cover Illustration: A. Johnson, Vivo Visuals Studio.

  • Rossetto et al.: Temporal Transitions in Fibrinolysis after Trauma: Adverse Outcome Is Principally Related to Late Hypofibrinolysis, p. 148

  • Myles and Medcalf: Fibrinolysis and Trauma Outcomes, p. 7