ON THE COVER:
The effect of intraoperative positive end-expiratory pressure (PEEP) and tidal volume settings on postoperative oxygenation and respiratory complications is unclear. In this issue of ANESTHESIOLOGY, Turan et al. tested whether ventilation using different tidal volumes and PEEP levels affects postoperative oxygenation for adult patients undergoing orthopedic surgery. In an accompanying editorial, Musch and Vidal Melo examine the current challenges and potential applications of intraoperative protective mechanical ventilation. Cover illustration: A. Johnson, Vivo Visuals Studio
Turan et al.: Tidal Volume and Positive End-expiratory Pressure and Postoperative Hypoxemia during General Anesthesia: A Single-center Multiple Crossover Factorial Cluster Trial, p. 406
Musch and Vidal Melo: Intraoperative Protective Mechanical Ventilation: Fact or Fiction?, p. 381