Binding of Anilide-type Local Anesthetics in Human PlasmaII. Implications In Vivo, with Special Reference to Transplacental Distribution

Binding of Anilide-type Local Anesthetics in Human Plasma: II. Implications In Vivo, with Special Reference to Transplacental Distribution

Geoffrey T. Tucker, Ph.D.;

Geoffrey T. Tucker, Ph.D.

*Research Investigator in Anesthesiology, Virginia Mason Research Center, Seattle, Washington 98101.

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Robert N. Boyes, Ph.D.;

Robert N. Boyes, Ph.D.

†Head, Drug Disposition Section, Astra Pharmaceutical Products, Inc, Worcester, Massachusetts 01606.

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Phillip O. Bridenbough, M.D.;

Phillip O. Bridenbough, M.D.

‡Staff Anesthesiologist, The Mason Clinic, Seattle, Washington 98101.

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Daniel C. Moore, M.D.

‡Staff Anesthesiologist, The Mason Clinic, Seattle, Washington 98101.

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Binding of Anilide-type Local Anesthetics in Human Plasma: II. Implications In Vivo, with Special Reference to Transplacental Distribution