The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in the 24-h period following anesthesia, but was the same after the first, second, and third anesthetics. Rats killed 24 h after a single anesthetic all had centrilobular hepatocellular necrosis. All animals killed 24 h after the second or third anesthetic also had centrilobular necrosis, but, in most animals, this was no more extensive than that following a single anesthetic, regardless of whether the interval between anesthetics was one or five days.
Hepatic Effects of Repeated Halothane Anesthetics in the Hypoxic Rat Model
Received from the Departments of Anaesthesia and Intensive Care and Pathology, Flinders Medical Centre, Bedford Park, South Australia. Accepted for publication April 13, 1987. Supported by a grant from the National Health and Medical Research Council of Australia.
John L. Plummer, Pauline de la M. Hall, Mark A. Jenner, Michael J. Cousins; Hepatic Effects of Repeated Halothane Anesthetics in the Hypoxic Rat Model. Anesthesiology 1987; 67:355–360 doi: https://doi.org/10.1097/00000542-198709000-00013
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