Skip Nav Destination
Article navigation
Education|
October 1988
Alfentanil Pharmacokinetics and Metabolism in Humans
Willem Meuldermans, Ph.D.;
Willem Meuldermans, Ph.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Achlel Van Peer, Ph.D.;
Achlel Van Peer, Ph.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Jan Hendrickx, Grad. Chem.;
Jan Hendrickx, Grad. Chem.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Robert Woestenborghs, Chem. Eng.;
Robert Woestenborghs, Chem. Eng.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
William Lauwers, Ph.D.;
William Lauwers, Ph.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Joseph Heykants, Ph.D.;
Joseph Heykants, Ph.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Gabriel Vanden Bussche, M.D.;
Gabriel Vanden Bussche, M.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Herbert Van Craeyvelt, M.D.;
Herbert Van Craeyvelt, M.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Paul Van Der Aa, M.D.
Paul Van Der Aa, M.D.
* Group Leader, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
† Staff Member, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
‡ Group Leader, Department of Analytical Research, Janssen Research Foundation.
§ Director, Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation.
¶ Director, International Clinical Research, Janssen Research Foundation.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium; present address: H. Familie Hospital, Ghent, Belgium.
** Staff Anesthesiologist, St. Elisabeth Hospital, Turnhout, Belgium.
Search for other works by this author on:
Anesthesiology October 1988, Vol. 69, 527–534.
Citation
Willem Meuldermans, Achlel Van Peer, Jan Hendrickx, Robert Woestenborghs, William Lauwers, Joseph Heykants, Gabriel Vanden Bussche, Herbert Van Craeyvelt, Paul Van Der Aa; Alfentanil Pharmacokinetics and Metabolism in Humans. Anesthesiology 1988; 69:527–534 doi: https://doi.org/10.1097/00000542-198810000-00012
Download citation file:
Citing articles via
Most Viewed
Related Articles
Pharmacogenetic Determinants of Human Liver Microsomal Alfentanil Metabolism and the Role of Cytochrome P450 3A5
Anesthesiology (March 2005)
Assessment of Cytochrome P450 3A4 Activity during the Menstrual Cycle Using Alfentanil as a Noninvasive Probe
Anesthesiology (July 1997)
Effect of Flumazenil on Ventilatory Drive during Sedation with Midazolam and Alfentanil
Anesthesiology (October 1996)
Is the Metabolism of Alfentanil Subject to Debrisoquine Polymorphism? A Study Using Human Liver Microsomes
Anesthesiology (October 1988)
Propofol Alters the Pharmacokinetics of Alfentanil in Healthy Male Volunteers
Anesthesiology (June 2001)