In Reply:--Werlhof has challenged Level 1's guarantee that 90% of HOTLINE(R) patients will wake up warm. Level 1's claim is supported by unpublished clinical data kept on file at the company. We found that, by changing only the infusion equipment during an extensive variety of elective surgical procedures, nine of ten patients ended the procedure warm, with temperatures greater or equal to 36 degrees C, or losing no more than 0.2 degree C.

Fluid warmers are an important method of heat conservation. [1]During anesthesia, average heat production decreases from roughly 70 kcal *symbol* h sup -1 to 40–60 kcal *symbol* h sup -1 (1 kcal *symbol* kg sup -1 *symbol* h sup -1). [2]Because 17 kcals are required to increase the temperature of 1 l of room temperature (20 degrees C) crystalloid to 37 degrees C, administering just 3 l of room temperature crystalloid would require the equivalent of nearly 1 h of an anesthetized patient's entire energy expenditure. With the specific heat of the body being 0.83 kcal *symbol* kg sup -1 *symbol* degrees C sup -1, 3 l of room temperature fluid would decrease body temperature by approximately 0.9 degree C.

Approximately 30 kcals are required to increase the temperature of 1 l of refrigerated blood (4 degrees C) to 37 degrees C. Therefore, approximately 0.5 h total energy expenditure is required to increase the temperature of 1 l of cold blood to 37 degrees C. One liter of refrigerated blood would decrease body temperature by approximately 0.5 degree C.

A study using HOTLINE and no other intraoperative warming devices conducted with 36 adult patients undergoing major orthopaedic and gynecologic surgery confirmed, "The HOTLINE fluid warmer … prevented accidental hypothermia in all patients." [3]Nineteen patients receiving HOTLINE therapy underwent surgery that lasted approximately 4 h and received approximately 4 l of intravenous fluids. No patients receiving HOTLINE therapy finished surgery with a body temperature below 35.5 degrees C.

Regarding the studies Werlhof cites that "demonstrate that fluid warming alone will not maintain normothermia," none involve a HOTLINE. All use old, conventional fluid-warming technologies with exposed patient tubing that fail to deliver body temperature fluids at any flow rate. Regarding the comment that "cooling at typical flow rates is trivial and of no consequence," the study referenced by Werlhof does not make, or even imply, this referenced conclusion. [4]Regarding Werlhof's statement that "intravenous fluid temperature cannot much exceed 40 degrees C without harming blood cells," it has been demonstrated that erythrocyte integrity is not heat-compromised until a temperature of 46 degrees C, [5]and the American Association of Blood Banks' standard has allowed blood warming to 42 degrees C since November 1994. [6].

Level 1 is committed to changing surgical results for the better, which is why Level 1 unconditionally guarantees HOTLINE. If any clinician is not satisfied with HOTLINE or its results, Level 1 will gladly make good on its money-back guarantee with no questions asked.

Barbara J. Lambert, Manager, I.V. Products, SIMS Level 1 Technologies, Inc., 160 Weymouth Street, Rockland, Massachusetts 02370.

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Morrison RC: Hypothermia in the elderly. Int Anesthesiol Clin 1988; 26:124-33.
Patel N, Smith CE, Costello F, Patterson L, Pinchak AC: Clinical comparison of two fluid warmers in adult patients. Can J Anaesth 1994; 41:A53.
Lee J, Mintz PD: A method for estimating the delivery temperature of intravenous fluids. Anesth Analg 1994; 79:155-9.
Uhl L, Pacini DG, Kruskall MS: The effect of heat on in vitro parameters of red cell integrity. Transfusion 1993; 33:60S.
Standards. 16th edition. Bethesda, American Association of Blood Banks, 1994.