To the Editor:-We read with interest the report of Setlock et al. [1]concerning the lack of tolerance to repeated doses of propofol used for sedation in pediatric radiation therapy patients. We, like Setlock et al., [1]and in contrast to Deer and Ridi, [2]have not seen tolerance to propofol develop in these patients. Specifically, in two recent patients accounting for more than 50 treatments, there was no increase in the induction and maintenance doses for sedation. We would like to add this experience to that of the authors.

James F. Mayhew, M.D., Professor; Amr E. Abouleish, M.D., Assistant Professor, Department of Anesthesiology, The University of Texas Medical Branch at Galveston, Suite 2A John Sealy, 301 University Boulevard, Galveston, Texas 77555-0591.

(Accepted for publication July 30, 1996.)

Setlock MA, Palmisano BW, Berens RJ, Rosner DR, Troshynski TJ, Murray K: Tolerance to propofol generally does not develop in pediatric patients undergoing radiation therapy. Anesthesiology 1996; 85:207-9.
Deer TR, Ridi GF: Propofol tolerance in a pediatric patient. Anesthesiology 1992; 77:828-9.