To the Editor:-The use of target-controlled infusion of hypnotics and analgesics recently reported (Jain et al. Anesthesiology 1996; 85:522–35) is further evidence of the use of pharmacokinetic model driven drug delivery or computer-assisted continuous infusion (CACI) of anesthetic drugs for use during cardiac surgery. Regrettably, the authors failed to acknowledge previous work in this area, [1–5] which makes their abstract claim “the use of target-controlled infusions of anesthetics for coronary artery graft surgery has not been studied in detail” most problematic. We refer the interested reader to the previously published material cited below.
J.G. Reves, M.D.
Professor and Chairman; Department of Anesthesiology
Robert N. Sladen, M.B., Ch.B.
Associate Professor and Vice Chairman; Department of Anesthesiology
Mark F. Newman, M.D.
Associate Professor and Chief; Division of Cardiac Anesthesiology; Duke University Medical Center; Durham, North Carolina