In Reply:-The papers cited by Dr. Reves et al. are among important contributions to the field of intravenous anesthetic infusions. Because of limitations of space, we were able to cite only those recent papers that were most directly relevant to our data. The sentence “the use of target-controlled infusions of anesthetics for coronary artery bypass graft surgery has not been studied in detail” was written because no previous study had evaluated the cardiovascular responses (including electrocardiographic, echocardiographic, and hemodynamic changes) to target-controlled infusions in such detail in a large multicenter population. We reaffirm our indebtedness to previous work by Reves et al. and other investigators.

Uday Jain, PhD., M.D.

Anesthesiology Service (129); Veterans Affairs Medical Center; 4150 Clement Street; San Francisco, California 94121; Assistant Professor Anesthesia; University of California, San Francisco