Anesthesia gas delivery equipment is a potentially important source of patient injury. To better define the contribution of gas delivery equipment to professional liability in anesthesia, the authors conducted an in-depth analysis of cases from the database of the American Society of Anesthesiologists Closed Claims Project.


The database of the Closed Claims Project is composed of closed US malpractice claims that have been collected in a standardized manner. All claims resulting from the use of gas delivery equipment were reviewed for recurrent patterns of injury.


Gas delivery equipment was associated with 72 (2%) of 3,791 claims in the database. Death and permanent brain damage accounted for almost all adverse outcomes (n = 55, 76%). Equipment misuse was defined as fault or human error associated with the preparation, maintenance, or deployment of a medical device. Equipment failure was defined as unexpected malfunction of a medical device, despite routine maintenance and previous uneventful use. Misuse of equipment (n = 54, 75%) was three times more common than equipment failure (n = 17, 24%). Misconnects and disconnects of the breathing circuit made the largest contribution to injury (n = 25, 35%). Reviewers judged that 38 of 72 claims (53%) could have been prevented by pulse oximetry, capnography, or a combination of these two monitors. Overall, 56 of 72 gas delivery claims (78%) were deemed preventable with the use or better use of monitors. The year of occurrence for claims involving gas delivery equipment ranged from 1962 to 1991 and did not differ significantly from claims involving other adverse respiratory events.


Claims associated with gas delivery equipment are infrequent but severe and continue to occur in the 1990s. Educational and preventive strategies that focus on equipment misuse and breathing circuit configuration may have the greatest potential for enhancing the safety of anesthesia gas delivery equipment.

Almost every piece of medical equipment carries some risk for misuse or failure. Anesthetic gas delivery devices are a particular concern because they exhibit several basic features that may predispose to critical events and subsequent patient injury. These include the presence of multiple connections, the use of complex mechanical components, and variations in manufacture and design.

We used the database of the American Society of Anesthesiologists (ASA) Closed Claims Project to conduct a detailed analysis of adverse outcomes associated with the use of gas delivery devices. The purpose of this study was to identify patterns of causation and strategies for prevention of injury that might not be evident from the study of isolated case reports or from data obtained under disparate investigative conditions.


The ASA Closed Claims Project is a structured evaluation of adverse anesthetic outcomes obtained from the closed claims files of 35 US professional liability insurance companies. Claims for dental damage are not included in this project. The database for the present study consists of 3,791 claims for adverse outcomes that occurred between 1961 and 1994. Three fourths (76%) of these claims occurred between 1980 and 1990.

A detailed description of the data collection process has been reported. [1] In brief, a closed claim file for an adverse anesthetic outcome typically consists of relevant hospital and medical records, narrative statements from involved health care personnel, expert and peer reviews, deposition summaries, outcome reports, and the cost of settlement or jury award. Each claim is reviewed by a practicing anesthesiologist according to a standardized set of instructions. The reviewer uses a standardized form to record information on patient characteristics, surgical procedures, sequence and location of events, critical incidents, clinical manifestations of injury, standard of care, and outcome. An adverse outcome is deemed preventable with better monitoring if the reviewer believes that the use or better use of any monitoring device probably would have prevented the outcome, regardless of whether such monitor was available at the time of the event. The reliability of reviewer judgments has been found to be acceptable. [2]

For the present study, gas delivery equipment was defined as any device used to convey gas to or from the endotracheal tube or mask. Claims involving endotracheal tubes and masks have been studied separately [3–5] and thus were not included here. Each claim related to a problem involving gas delivery equipment was assigned to one of six basic equipment groups: anesthesia machine, breathing circuit, supplemental oxygen delivery tubing, gas supply tank or line, vaporizer, or mechanical ventilator (Table 1).

Table 1. Equipment Groups 

Table 1. Equipment Groups 
Table 1. Equipment Groups 

Each claim file was examined for evidence of equipment misuse or failure. Equipment misuse was used to characterize claims in which the injury originated from human fault or error associated with the preparation, maintenance, or deployment of a medical device. An example of equipment misuse is the installation of a PEEP valve on the inspiratory limb of the breathing circuit. Equipment failure was used to characterize claims in which the device appeared to malfunction unexpectedly, despite routine maintenance and previous uneventful use. An example of equipment failure is a unidirectional ventilator valve that suddenly failed to open. A designation of uncertain was applied to cases in which the claim file did not contain enough information to distinguish between a primary role for misuse or failure. In keeping with Cooper's classification scheme, [6] breathing circuit disconnects that persisted to the point of patient injury were considered examples of faulty intraoperative maintenance and thus were classified as equipment misuse.

Each claim was further characterized by an initiating event, a mechanism of injury, and an adverse outcome. An initiating event was defined as the aspect of equipment usage or function that was identified in the records as the key or critical starting point for evolution of the injury. An example of an initiating event is the detachment of a ventilator hose from the breathing circuit. Mechanism of injury was defined as the physiologic process or abnormality that played the primary role in producing the adverse outcome. Overdose of an inhalational anesthetic is an example of a mechanism of injury. Adverse outcome was defined as the actual injury sustained by the patient.

Several specific terms were used to describe recurrent initiating events. A disconnect was defined as the loss of attachment or continuity in a breathing circuit that was initially configured in a functional and conventional manner. A misconnect was defined as a nonfunctional and unconventional configuration of breathing circuit components or attachments. An oxygen switch was defined as the unintended substitution of an oxygen supply tank or supply line with another tank or line that did not contain or convey 100% oxygen.

Payments for settlement and jury award were expressed in original dollar amounts, without adjustment for inflation. Because payments did not exhibit a normal distribution, the median and range were used as descriptive measures. Statistical comparisons of payment distributions were made using the Kolmogorov-Smirnov test, with P <or= to 0.05 considered significant. The same method was used to compare the distribution of occurrence dates for gas delivery claims versus other claims.


Gas delivery equipment accounted for 72 of 3,791 claims (2%) in the ASA Closed Claims database. The most common adverse outcomes were death and brain damage (n = 55, 76%;Table 2). Almost all adverse events associated with gas delivery equipment occurred in the operating room (n = 62, 86%;Table 3). The breathing circuit was the most common source of injury, accounting for 28 of 72 claims (39%;Table 2). Vaporizers (n = 15), ventilators (n = 12), and supply tanks or lines (n = 8) accounted for 49% of gas delivery claims. Events associated with the anesthesia machine were comparatively rare (n = 5, 7%).

Table 2. Adverse Outcomes 

Table 2. Adverse Outcomes 
Table 2. Adverse Outcomes 

Table 3. Occurrence Sites 

Table 3. Occurrence Sites 
Table 3. Occurrence Sites 

Equipment misuse (n = 54, 75%) was three times more frequent than equipment failure (n = 17, 24%;Table 4). Two thirds of claims involving misuse (38 of 54, 70%) resulted directly and almost exclusively from the actions of the primary anesthesia provider (i.e., anesthesiologist or nurse anesthetist). In the remaining 16 claims (30%), misuse resulted, at least in part, from the contributory actions of ancillary personnel such as technicians, engineers, suppliers, or nurses in the postanesthesia care unit (PACU) or intensive care unit (ICU). The role of ancillary personnel was especially prominent in claims involving a switch in oxygen supply (all seven cases). The contributory actions in these cases included crossed installation of supply lines at the back of the anesthesia machine by technicians (four cases), crossed installation of central supply lines by construction personnel (one case), delivery of the wrong central tank by a gas supplier (one case), and unannounced nitrogen flushing of central oxygen lines by service engineers (one case). Actions of nursing personnel contributed to four of the six injuries that took place in the PACU. Three of these claims involved supplemental oxygen supply tubing that had been misused by creating a direct attachment between the wall oxygen source and the endotracheal tube. One other PACU claim involved a disconnect that occurred while a ventilator-dependent patient was left unattended by the recovery room nurse. Nurses or respiratory therapists played a contributory role in three of the four injuries that took place in the ICU by disabling a low-pressure disconnect alarm, by using a ventilator that had a misinstalled valve, and by creating a direct attachment between the wall oxygen source and the endotracheal tube (one case each). One intraoperative event involving the breathing circuit was linked to backward installation of a one-way valve by a service technician.

Table 4. Misuse and Failure 

Table 4. Misuse and Failure 
Table 4. Misuse and Failure 

Two initiating events accounted for more than one third of all gas delivery claims (n = 25, 35%): misconnects (n = 14, 19%) and disconnects (n = 11, 15%). The three most frequently specified sites for disconnects and misconnects were the junction between the breathing circuit and the gas delivery outlet of the ventilator (9 of 25 cases, 36%), the junction between the distal end of the breathing circuit and the endotracheal tube (4 of 25 cases; 16%), and a location on the inspiratory limb of the breathing circuit that allowed the interposition of a PEEP valve (3 of 25 cases; 12%). The site of misconnect or disconnect was unspecified or unknown in 6 of 25 cases (24%). Other types of initiating events occurred at a frequency of 10% or less and usually were characterized by operator errors such as failure to turn on a device, selecting the wrong knob or dial, or the misinstallation of valves, gas lines, or gas tanks (Table 5). Switches involving oxygen supply more often were associated with supply lines (six cases) than supply tanks (one case).

Table 5. Initiating Events 

Table 5. Initiating Events 
Table 5. Initiating Events 

Inadequate oxygenation was the primary mechanism of injury in approximately half of the claims (n = 38, 53%). This mechanism was associated with all disconnects, oxygen supply switches, and failures to turn on the ventilator. Two other mechanisms of injury accounted for most of the remaining claims: excessive airway pressure (n = 13, 18%) and overdose of inhalational anesthetic (n = 12, 17%). Claims involving excessive airway pressure exhibited two recurrent errors: incorrect connection of a breathing circuit hose to the ventilator (five cases), and use of supplemental oxygen delivery tubing in a PACU or ICU setting to create a direct connection between a source of wall oxygen and the endotracheal tube (four cases). Overdose of inhalational anesthetic was associated with three basic problems: valve malfunction within the vaporizer (five cases), spillage of liquid inhalational agent into the breathing circuit (two cases), and choice of the wrong dial or setting (two cases).

Most of the gas delivery claims resulted from events that took place in the decade of the 1980s (n = 49, 68%), with occurrence dates ranging from 1962 to 1991 (Table 6). Injuries related to gas delivery equipment represented 2%(53/3,037) of all claims occurring during or after 1980 and 1%(18/1495) of all claims occurring during or after 1985. The distribution of occurrence dates for gas delivery claims was not significantly different from other types of adverse respiratory events. Gas delivery claims tended to be earlier in occurrence than nonrespiratory claims (P <or= to 0.01, Table 6). Of note, claims involving anesthesia machines, ventilators, and oxygen supply lines and tanks all predated 1990. Claims resulting from breathing circuits, vaporizers, and supplemental O2tubing continued to occur in the 1990s.

Table 6. Year of Event 

Table 6. Year of Event 
Table 6. Year of Event 

A focused analysis of the eight claims involving vaporizer failure revealed an interesting contrast between older and newer claims. Six of the eight claims for vaporizer failure occurred before 1985, and all six resulted in brain damage or death. The initiating event in five of the six claims was vaporizer valve malfunction (spool valve or check valve). In one of the six claims, an initiating event was not explicitly identified, but liquid inhalation agent was found in the CO2canister, and experts who reviewed the case cited similar problems with that model of vaporizer. In contrast, the two more recent claims involving vaporizer failure (1990 and 1991) were associated with intraoperative awareness. Both of the recent claims were caused by the delivery of inhalation agents at concentrations that were lower than intended. In one case, inadequate agent delivery was attributed to a leak produced by a missing vaporizer O-ring. In the other case, the claim file simply indicated that the vaporizer underwent subsequent testing and that the device was “not delivering the prescribed concentration.”

Reviewers judged that the use or better use of monitoring could have prevented injury in 56 of 72 gas delivery claims (78%), including 11 (61%) of the 18 claims occurring between 1985 and 1991. Reviewers identified a preventive role for the following monitors: pulse oximeter (35 cases), capnograph (25 cases), anesthetic agent analyzer (12 cases), oxygen analyzer (9 cases), airway pressure alarm (7 cases), and precordial or esophageal stethoscope (1 case). In 9 of 56 cases (16%), a mechanical monitor or alarm (e.g., oxygen analyzer, high- or low-pressure circuit alarm, oxygen-ratio monitor controller) that could have played a preventative role was physically present as an anesthesia machine attachment or component, but was either turned off or broken. In three cases (5%), a mechanical monitor or alarm that could have played a preventative role was not physically present as an attachment or component on the anesthesia machine. Claims that reviewers did not consider preventable with better monitoring (16 of 72; 22%) typically involved situations in which the initiating event progressed rapidly to a point at which it created an injurious physiologic process. Examples include barotrauma produced by attaching an endotracheal tube directly to a 50 psi source of oxygen and cardiovascular depression produced by spilling liquid inhalation agent into the breathing circuit.

Overall, 38 claims (53%) were considered preventable if a pulse oximeter, capnograph, or a combination of these two monitors had been used. Of note, there were two claims in which human factor issues related to judgment and attention negated the preventive value of pulse oximetery or capnography. In the first case, the pulse oximeter indicated the presence of hypoxemia, but the anesthesiologist interpreted the low reading as an artifact of probe position. In the second case, the anesthesiologist forgot to resume ventilation after separation from cardiopulmonary bypass. The delayed detection of apnea was attributed to the fact that the audible alarms for the pulse oximeter and capnograph had been disabled during bypass and had not been reactivated. Both patients sustained permanent brain damage.

Payment for settlement or jury award was received in 76% of claims involving gas delivery equipment. The median payment in these claims was $306,000 (range, $542 to $6,337,000). This is comparable with the payment for other adverse respiratory events in the Closed Claims database (median, $230,000; range, $390-$6,300,000), but significantly higher than nonrespiratory events (median, $50,000; range, $15-$23,000,000; P < 0.01 between payment distributions).


During the past two decades, large-scale surveys of anesthetic outcome have identified gas delivery equipment as a small but recurrent cause of serious injury. [7–13] These studies attribute approximately 1–5% of anesthesia-related death and brain damage to problems with gas delivery equipment. The ASA Closed Claims Project provides similar data, with gas delivery equipment accounting for 3% of claims for death (34/1277) and 5% of claims for brain damage (21/466).

Gas delivery equipment plays a prominent role in critical incident studies, often contributing to more than 20% of all reported events. [6,14–19] In contrast, claims involving gas delivery equipment account for only 2%(72/3791) of the overall ASA Closed Claims database. This difference may result, at least in part, from a key distinction between closed claims and critical incidents. Almost all claims in the ASA Closed Claims database (97%) involve an identifiable injury. Critical incidents are events that have the potential to cause injury. Thus, many critical incidents are detected and remedied before an identifiable injury occurs. For example, only 17% of critical incidents in Cooper's 1978 study [6] had more than a transient physiologic effect, and only 26% of incidents in the recent Australian Incident Monitoring Study [20] were associated with either a major physiologic change, morbidity, or death. From this perspective, it is not surprising that gas delivery equipment accounts for a comparatively small proportion of claims in the Closed Claims Project. A willingness (or reluctance) to volunteer reports about certain types of critical incidents also may contribute to some of the observed differences. Finally, gas delivery claims may be underrepresented in the Closed Claims database because some equipment-related lawsuits may be filed against manufacturers instead of anesthesiologists.

Gas delivery depends on the use of equipment with multiple connections and moving parts. On this basis, one might expect equipment failure to play a particularly important role. Instead, the frequency of equipment misuse was three times greater than equipment failure (75% vs. 24%). This is consistent with previous studies, [6,14–16] which have emphasized the prominent role of human error in equipment-related critical incidents and adverse outcomes. In the present study, the breathing circuit made the single largest contribution to misuse of gas delivery equipment (26 of 54 claims involving misuse, 48%;Table 4). This is a notable finding, particularly when one considers the physical simplicity of the breathing circuit compared with the complexity of ventilators, vaporizers, and anesthesia machines. Almost all adverse outcomes resulting from the breathing circuit involved a misconnect or disconnect (25/28, 89%;Table 5). This feature suggests that human factors associated with making and maintaining breathing circuit connections are a particularly appropriate target for injury prevention. Two recent overviews suggest that this problem may require focused educational efforts and perhaps a fundamental re-evaluation of breathing circuit design. [21,22]

Another distinctive feature of breathing circuit claims was the observation that misconnects (14) were as prevalent as disconnects (11;Table 5). This differs from critical incident studies in which disconnects usually outnumber misconnects by a factor of two or more. [16–18] Although the disparity may simply be a result of the small number of cases, the finding may reflect a key difference in the speed of evolution for high- and low-pressure injuries of the airway. Misconnects typically occur in an intact circuit, and thereby lead to high airway pressure and the potential for pneumothorax. If a pneumothorax ensues, especially in the setting of mechanical ventilation, it may rapidly progress to a state of severe cardiorespiratory depression or arrest. In contrast, disconnects produce partial or complete disruption of breathing circuit integrity and thereby lead to low airway pressure. If circuit disruption is incomplete or if the clinical setting is compatible with respiratory reserve (i.e., high FIO2and a low or normal PaCO2), the evolution of hypoxia and hypercapnia may be slow enough to permit detection and correction of the problem before substantial injury occurs. We speculate that the relative prominence of breathing circuit misconnects in the ASA Closed Claims database reflects the comparatively swift and poorly reversible cascade of events that accompany high airway pressure. These observations underscore the importance of breathing circuit monitors that can issue prompt alarms for high- and low-pressure conditions.

An interesting aspect of the present study was the observation that ancillary personnel can make an important contribution to the anesthesiologist's liability. Misuse of equipment by technicians, engineers, nurses, and respiratory therapists contributed to patient injury in one fifth of all claims related to gas delivery equipment (16 cases). Ancillary personnel played an especially prominent role in claims involving switches in oxygen supply and the misuse of supplemental oxygen tubing. These findings suggest a role for preventive strategies and educational efforts that extend beyond the boundaries of the operating room and intraoperative anesthesia.

Inspection or “checkout” of anesthesia apparatus often is cited as a practice that can reduce the likelihood of equipment-related injury. [6,14–18,23–25] In the present study, we were unable to make a formal evaluation of such protocols because the claim files did not contain enough detail to reliably assess the merits of specific checkout procedures. From an informal perspective, we can offer a potentially useful observation. Checkout protocols typically entail four basic activities: verification of back-up equipment and supplies (e.g., pressurized gas cylinders); inspection of equipment configurations (e.g., breathing circuit connections); inspection of equipment mechanics (e.g., proper action of unidirectional valves); and preparation of monitors (e.g., calibration, verification of function, and activation of alarms). It is noteworthy that most adverse outcomes in the present study were considered preventable with the use or better use of monitors (56 of 72 claims, 78%). Moreover, 9 of the 56 preventable outcomes (16%) occurred in cases where the monitor was turned off or broken. These features suggest that the effectiveness of checkout protocols may be enhanced by emphasizing the basic aspects of monitor selection and use.

The limitations of closed claims analysis have been described in previous reports. [1,3,4] These limitations include the inability to provide numerical estimates of risk (because of lack of denominator data), the absence of rigorous comparison groups, a probable bias toward adverse outcomes, and partial reliance on data from direct participants rather than impartial observers. The use of a large group of reviewers increases concerns about interrater reliability, but tests of Closed Claims reviewers have demonstrated statistically significant agreement for basic aspects of clinical care. [2] It is important to remember that judgments of preventability in this study are based on the assumption of optimal use of monitors, the correct identification of all detectable problems, and the timely implementation of appropriate remedies. Thus, the estimates given here should be regarded as near-maximal or ideal values.

Two additional limitations of closed claims analysis may affect the applicability of these findings to current practice. The first limitation concerns the age of claims. For rare events, long periods of data collection are necessary because recurrent patterns of injury are difficult to discern when the acquisition interval is short and the number of available claims is small. Further, the Closed Claims database cannot capture the most recent claims because a 3- to 5-year interval typically elapses between the occurrence date of a claim and its actual entry into the project database. This interval reflects the process of claim assessment and resolution and the logistical tasks associated with scheduling reviews and deploying reviewers to distant sites. The second limitation concerns missing or unavailable information. This second limitation occurs because data of potential interest (such as equipment model numbers and dates of manufacture) are sometimes absent in the claim file or overlooked during the onsite review. Taken together, these two limitations make it difficult to determine if the basic patterns of injury observed in gas delivery claims are relevant to the mix of equipment that is now in clinical use. Although we cannot address this issue in a rigorous manner, some insight can be gained by examining the recent literature for letters and case reports that describe problems associated with gas delivery equipment. A MedLine[trademark symbol] search of the anesthesiology literature between January 1990 and December 1995, plus a Current Contents[trademark symbol] search in 1996, yielded 10 English-language letters and case reports involving the breathing circuit, [26–30] vaporizer, [31,32] ventilator, [33,34] and anesthesia machine. [35] The presence of these case reports suggests that problems with gas delivery equipment have not been completely resolved by the evolution of equipment design and the availability of newer devices. From this perspective, some of the insights available from closed claims analysis still may be applicable to contemporary clinical practice and risk-management efforts.

In summary, claims involving gas delivery equipment represent a small fraction of the ASA Closed Claims database. These claims are characterized by high severity of injury, high cost, and a prominent role for equipment misuse. The breathing circuit represents the single largest source of gas delivery equipment claims, and almost all of these claims result from misconnects or disconnects.

The authors thank the members of the American Society of Anesthesiologists who have served as reviewers for the Closed Claims Project. A list of reviewers is available from the authors.

The following 27 organizations have given permission for acknowledgment as a source of closed claims: Anesthesia Services Medical Group, Inc., California, Anesthesiologists Professional Assurance Trust, Florida, Armed Forces Institute of Pathology, Controlled Risk Insurance Company (Harvard), COPIC Insurance Company, Colorado, Doctors' Company of Southern California, Illinois State Medical Inter-Insurance Exchange, Massachusetts Medical Professional Insurance Association, Medical Association of Georgia Mutual Insurance Company, Medical Inter-Insurance Exchange of New Jersey, Medical Liability Mutual Insurance Company of New York, Medical Mutual Insurance Company of Maine, Midwest Medical Insurance Company, Mutual Insurance Company of Arizona, National Capital Reciprocal Insurance Company, NORCAL Mutual Insurance Company, California, Pennsylvania Medical Society Liability Insurance Company, PHICO Insurance Company, Pennsylvania, Physicians Insurance Company of Wisconsin, PIE Mutual Insurance Company, Ohio, Preferred Physicians Mutual Risk Retention Group, St. Paul Fire and Marine Insurance Company, State Volunteer Mutual Insurance Company, Tennessee, University of Texas Medical System, Utah Medical Insurance Association, Veterans Administration, Washington State Physicians Insurance Exchange Association.


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