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Table of Contents

Anesthesiology June 2013, Vol. 118, A13–A18. https://doi.org/10.1097/ALN.0b013e31829a0b2e

Editorial Board

Anesthesiology June 2013, Vol. 118, A15–A16. https://doi.org/10.1097/ALN.0b013e31829a0b0d

This Month in Anesthesiology

Anesthesiology June 2013, Vol. 118, A1. https://doi.org/10.1097/ALN.0b013e31829a0a64

Anesthesiology CME Program

Anesthesiology June 2013, Vol. 118, A19. https://doi.org/10.1097/ALN.0b013e31829a0afc

Editorial

Anesthesiology June 2013, Vol. 118, 1245–1246. https://doi.org/10.1097/ALN.0b013e318291031f
Anesthesiology June 2013, Vol. 118, 1247–1249. https://doi.org/10.1097/ALN.0b013e31829303c7
Anesthesiology June 2013, Vol. 118, 1250–1251. https://doi.org/10.1097/ALN.0b013e3182923ea4
Anesthesiology June 2013, Vol. 118, 1252–1253. https://doi.org/10.1097/ALN.0b013e31828e13e9
Anesthesiology June 2013, Vol. 118, 1254–1257. https://doi.org/10.1097/ALN.0b013e3182910309
Anesthesiology June 2013, Vol. 118, 1258–1260. https://doi.org/10.1097/ALN.0b013e31829106cd
Anesthesiology June 2013, Vol. 118, 1261–1263. https://doi.org/10.1097/ALN.0b013e31829107d5

Perioperative Medicine

Anesthesiology June 2013, Vol. 118, 1264–1275. https://doi.org/10.1097/ALN.0b013e31829103f5

This study demonstrates in human surgical patients that both GABAergic and non-GABAergic anesthetics disrupt frontal–parietal communication, despite distinct neurophysiologic profiles

Supplemental Digital Content is available in the text.

Anesthesiology June 2013, Vol. 118, 1276–1285. https://doi.org/10.1097/ALN.0b013e318293065c

The authors developed a score for the prediction of postoperative respiratory complications based on five preoperative patients’ characteristics. It can be used preoperatively by anesthesiologists to identify patients at increased risk for severe postoperative respiratory complications.

Anesthesiology June 2013, Vol. 118, 1286–1297. https://doi.org/10.1097/ALN.0b013e3182923da0

The recommended maximum surgical blood order schedule (MSBOS) for common surgical procedures that was published over 30 yr ago may be obsolete because many new procedures have been introduced while others have been improved upon. Data on 53,526 surgical patients having 1,632 types of surgical procedures were acquired from an anesthesia information management system (AIMS). The type and crossmatch–to–transfusion ratios of all surgical services except cardiac and vascular/transplant greatly exceeded the proposed optimal ratio of 2. An updated, institution-specific MSBOS for each surgical specialty was created from a novel blood order algorithm and the AIMS data. Implementing the algorithm and an institution-specific MSBOS could improve operating room efficiency, enhance patient safety, and reduce costs.

Supplemental Digital Content is available in the text.

Anesthesiology June 2013, Vol. 118, 1298–1306. https://doi.org/10.1097/ALN.0b013e31828e12b3

The authors estimate a baseline risk index for in-hospital mortality using present-on-admission indicators and show that hospital performance measures appear to be dependent on whether or not the underlying model includes hospital-acquired conditions.

Anesthesiology June 2013, Vol. 118, 1307–1321. https://doi.org/10.1097/ALN.0b013e31829102de

A protective mechanical ventilation strategy during open abdominal surgery may influence postoperative modified Clinical Pulmonary Infection Score, arterial blood gases, and pulmonary functional tests.

Anesthesiology June 2013, Vol. 118, 1322–1331. https://doi.org/10.1097/ALN.0b013e31829107b8

Nitrous oxide administration induces leukocyte DNA damage in patients undergoing major colorectal surgery. DNA damage was associated with postoperative wound infection.

Anesthesiology June 2013, Vol. 118, 1332–1340. https://doi.org/10.1097/ALN.0b013e318289b84b

This study consisted of the development and psychometric evaluation of a short-form 15-item patient-rated postoperative quality of recovery score, the QoR-15. The QoR-15 is a valid, reliable, responsive, and clinically acceptable measure of postoperative quality of recovery.

Supplemental Digital Content is available in the text.

Anesthesiology June 2013, Vol. 118, 1341–1349. https://doi.org/10.1097/ALN.0b013e318289bb30

The entropy of the acoustic signal from a microphone placed over the trachea can detect apnea in sedated volunteers with satisfactory sensitivity and specificity, and provide an early warning of the onset of apnea.

Anesthesiology June 2013, Vol. 118, 1350–1361. https://doi.org/10.1097/ALN.0b013e31828ce74d

The sink mechanism results in a redistribution of anesthetic from tissues to the blood stream. However, the extent to which this occurs and the associated timescale may not be adequate to explain the dramatic recoveries observed clinically.

Anesthesiology June 2013, Vol. 118, 1362–1372. https://doi.org/10.1097/ALN.0b013e31828c23f8

Stroke is a risk factor for fracture and 1–1.5% of stroke patients suffer a fracture within 24 h of a stroke. The authors showed that fracture enhances stroke injury via HMGB1 release and macrophage/microglia brain infiltration.

Anesthesiology June 2013, Vol. 118, 1373–1384. https://doi.org/10.1097/ALN.0b013e31828a7039

Atorvastatin-induced cardioprotection of human myocardium involves activation of tumor necrosis factor-α, Janus kinase-2, and signal transducers and activators of transcription-3, and inhibition of the mitochondrial Permeability Transition Pore opening in early reoxygenation.

Anesthesiology June 2013, Vol. 118, 1385–1394. https://doi.org/10.1097/ALN.0b013e31828744c0

Compared to isoflurane and s-ketamine, xenon limited progressive adverse cardiac remodeling and contractile dysfunction 28 days after perioperative myocardial infarction.

Anesthesiology June 2013, Vol. 118, 1395–1407. https://doi.org/10.1097/ALN.0b013e31828e1544

Remifentanil has no effect on its synergistic relation with propofol with respect to the bispectral index in patients with the A118G genetic polymorphism. Noxious stimulation increases requirements of remifentanil by 4%.

Anesthesiology June 2013, Vol. 118, 1408–1416. https://doi.org/10.1097/ALN.0b013e31828afc16

The effects of GM1 ganglioside on amyloid β-protein fibrillogenesis have not been reported. The results of the current study suggested that propofol and thiopental have direct and indirect inhibitory effects on amyloid β-protein fibrillogenesis.

Anesthesiology June 2013, Vol. 118, 1417–1425. https://doi.org/10.1097/ALN.0b013e318289bcd3

Benzodiazepines act in the nervous system by potentiating the function of the γ-aminobutyric acid type A receptor. The authors present novel data that demonstrate that the benzodiazepine diazepam acts by increasing the channel gating efficacy.

Critical Care Medicine

Anesthesiology June 2013, Vol. 118, 1426–1436. https://doi.org/10.1097/ALN.0b013e31828baa67

In sepsis, oxygen utilization can be impaired. Hypoxia-inducible factor-1α, the key player in adaptation to inflammation/hypoxia, was suppressed both in leukocytes from septic patients and in endotoxin-tolerant monocytic cells. This might contribute to disturbed adaptation to tissue hypoxia in sepsis.

Pain Medicine

Anesthesiology June 2013, Vol. 118, 1437–1445. https://doi.org/10.1097/ALN.0b013e318291079c

Propofol can induce respiratory depression including lethal apnea. Coadministration of AMPAKINE CX717 with propofol markedly reduced propofol-induced respiratory depression and thus increases the safety margin against profound apnea and death.

Education: Case Scenario

Anesthesiology June 2013, Vol. 118, 1446–1454. https://doi.org/10.1097/ALN.0b013e3182923e8a

Education: Images in Anesthesiology

Anesthesiology June 2013, Vol. 118, 1455. https://doi.org/10.1097/ALN.0b013e31826e05a7
Anesthesiology June 2013, Vol. 118, 1456. https://doi.org/10.1097/ALN.0b013e31826f3229

Education: Anesthesia Literature Review

Anesthesiology June 2013, Vol. 118, 1457–1459. https://doi.org/10.1097/ALN.0b013e318293338a

Education: Clinical Concepts and Commentary

Anesthesiology June 2013, Vol. 118, 1460–1465. https://doi.org/10.1097/ALN.0b013e31828f4fc3

Positive inotropic agents should be used judiciously when managing surgical patients with acute myocardial ischemia–reperfusion injury, as use of these inotropes is not without potential adverse effects.

Education: Review Article

Anesthesiology June 2013, Vol. 118, 1466–1474. https://doi.org/10.1097/ALN.0b013e318289bcba

Education: Mind to Mind

Anesthesiology June 2013, Vol. 118, 1475–1476. https://doi.org/10.1097/ALN.0b013e31825e6ca9
Anesthesiology June 2013, Vol. 118, 1477–1478. https://doi.org/10.1097/ALN.0b013e3182784cae

Correspondence

Anesthesiology June 2013, Vol. 118, 1479–1480. https://doi.org/10.1097/ALN.0b013e31829101fa
Anesthesiology June 2013, Vol. 118, 1481. https://doi.org/10.1097/ALN.0b013e3182910492
Anesthesiology June 2013, Vol. 118, 1481–1482. https://doi.org/10.1097/ALN.0b013e3182910473
Anesthesiology June 2013, Vol. 118, 1482. https://doi.org/10.1097/ALN.0b013e31828fc802
Anesthesiology June 2013, Vol. 118, 1482–1483. https://doi.org/10.1097/ALN.0b013e31828fdf77
Anesthesiology June 2013, Vol. 118, 1483–1484. https://doi.org/10.1097/ALN.0b013e318291c32b
Anesthesiology June 2013, Vol. 118, 1484. https://doi.org/10.1097/ALN.0b013e318291d923
Anesthesiology June 2013, Vol. 118, 1484–1485. https://doi.org/10.1097/ALN.0b013e318291d93b

Reviews of Educational Material

Anesthesiology June 2013, Vol. 118, 1486. https://doi.org/10.1097/ALN.0b013e3182829ba7
Anesthesiology June 2013, Vol. 118, 1486–1487. https://doi.org/10.1097/ALN.0b013e31828ce645

Acknowledgment

Anesthesiology June 2013, Vol. 118, 1488–1490. https://doi.org/10.1097/ALN.0b013e3182959340

Anesthesiology Reflections from the Wood Library-Museum

Anesthesiology June 2013, Vol. 118, 1260. https://doi.org/10.1097/ALN.0b013e31829a0b3d
Anesthesiology June 2013, Vol. 118, 1263. https://doi.org/10.1097/ALN.0b013e31829a0b4b
Anesthesiology June 2013, Vol. 118, 1340. https://doi.org/10.1097/ALN.0b013e31829a0b59
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