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Anesthesiology November 2013, Vol. 119, A13–A17. https://doi.org/10.1097/01.anes.0000436968.26228.9a

Editorial Board

Anesthesiology November 2013, Vol. 119, A17–A18. https://doi.org/10.1097/01.anes.0000436967.26228.7e

This Month in Anesthesiology

Anesthesiology November 2013, Vol. 119, A1. https://doi.org/10.1097/01.anes.0000436965.41475.52

Anesthesiology CME Program

Anesthesiology November 2013, Vol. 119, A21. https://doi.org/10.1097/01.anes.0000436966.18604.4e

Editorial

Anesthesiology November 2013, Vol. 119, 999–1000. https://doi.org/10.1097/ALN.0b013e3182a951a2
Anesthesiology November 2013, Vol. 119, 1001–1002. https://doi.org/10.1097/ALN.0b013e3182a950fb
Anesthesiology November 2013, Vol. 119, 1003–1005. https://doi.org/10.1097/ALN.0b013e3182a7cad1
Anesthesiology November 2013, Vol. 119, 1006–1008. https://doi.org/10.1097/ALN.0b013e3182a8a90c
Anesthesiology November 2013, Vol. 119, 1009–1010. https://doi.org/10.1097/ALN.0b013e3182a76fa6
Anesthesiology November 2013, Vol. 119, 1011–1013. https://doi.org/10.1097/ALN.0b013e3182a9521b

Special Articles

Anesthesiology November 2013, Vol. 119, 1014–1022. https://doi.org/10.1097/ALN.0b013e3182a771ea
Anesthesiology November 2013, Vol. 119, 1023–1030. https://doi.org/10.1097/ALN.0b013e31829b382f

Perioperative Medicine

Anesthesiology November 2013, Vol. 119, 1031–1042. https://doi.org/10.1097/ALN.0b013e3182a7ca92

Supplemental Digital Content is available in the text.

Both simultaneous electroencephalographic and functional magnetic resonance imaging measurement confirmed a decreased connectivity in frontoparietal feedback networks with propofol-induced unconsciousness.

Anesthesiology November 2013, Vol. 119, 1043–1053. https://doi.org/10.1097/ALN.0b013e3182a8a8e7

Supplemental Digital Content is available in the text.

In 870 volunteers not ascertained for malignant hyperthermia susceptibility, numerous variants in RYR1 and CACNA1S genes were observed, some consistent and others inconsistent with presumed pathogenicity in current databases.

Anesthesiology November 2013, Vol. 119, 1054–1065. https://doi.org/10.1097/ALN.0b013e3182a8a998

Exome sequencing of DNAs from four pedigrees associated with malignant hyperthermia identified novel genetic variant in each. The increased sensitivity of exome sequencing combined with allele frequency data is a powerful approach to identify rare genetic variants–associated malignant hyperthermia.

Anesthesiology November 2013, Vol. 119, 1066–1077. https://doi.org/10.1097/ALN.0b013e31829f68cf

There were an average of about 100 flow disturbances per case. One third of the disturbances were related to operating room layout and design.

Anesthesiology November 2013, Vol. 119, 1078–1086. https://doi.org/10.1097/ALN.0b013e3182a10b40

Individual pulsed wave Doppler and tissue Doppler indices of left ventricular diastolic function are subject to change with increasing positive end-expiratory pressure in postoperative cardiac surgery patients. The presence of positive pressure ventilation should thus be taken into account when evaluating echocardiographic indices of diastolic function.

Anesthesiology November 2013, Vol. 119, 1087–1095. https://doi.org/10.1097/ALN.0b013e31829e47e3

Supplemental Digital Content is available in the text.

Molecular modeling revealed a putative intersubunit binding site for propofol that predicted the potency of propofol congeners for receptor potentiation. This approach might provide the basis for high-throughput in silico screening of novel anesthetic compounds.

Anesthesiology November 2013, Vol. 119, 1096–1108. https://doi.org/10.1097/ALN.0b013e31829e4b05

Bumetanide, a selective inhibitor of the transporter NKCC1, reduced neuroexcitatory effects in hippocampal slices and increased sedation by midazolam in neonatal rat. The neuroexcitatory effects and reduced sedative activity of midazolam in neonatal rats appear to involve increased intracellular chloride produced by NKCC1.

Anesthesiology November 2013, Vol. 119, 1109–1119. https://doi.org/10.1097/ALN.0b013e31829d4a92

Treatment of hemorrhage-induced hypotension and reductions in potential amplitude was less effective with phenylephrine than with epinephrine, which also increased cardiac output and oxygen delivery. This animal model suggests that monitoring cardiac output facilitates treatment of hemorrhage-induced reductions in motor-evoked potentials in spine surgery.

Critical Care Medicine

Anesthesiology November 2013, Vol. 119, 1120–1136. https://doi.org/10.1097/ALN.0b013e31829c2d90

Supplemental Digital Content is available in the text.

Spectroscopy in a highly controlled brain oxygen–glucose-deprivation slice model using neonatal rats was used during three different mild hypothermia protocols. Starting mild hypothermia simultaneously with oxygen–glucose-deprivation compared with delayed or no hypothermia is associated with higher pyruvate carboxylase throughput. This suggests that glial integrity is one key component of the neuroprotective effect of mild hypothermia.

Anesthesiology November 2013, Vol. 119, 1137–1148. https://doi.org/10.1097/ALN.0b013e3182a2a265

Given after traumatic injury to hippocampal slices, xenon (and argon to a lesser degree) halves the secondary neuronal injury. N-methyl-d-aspartate antagonism is an important component of this protective effect.

Pain Medicine

Anesthesiology November 2013, Vol. 119, 1149–1162. https://doi.org/10.1097/ALN.0b013e3182a951fc

In a review of over 634 individuals in the Cleveland Family Study, a study of genetics in obstructive sleep apnea, nocturnal oxyhemoglobin desaturation was independently associated with morning headache, headache disrupting sleep, chest pain while in bed, and pain disrupting sleep.

Anesthesiology November 2013, Vol. 119, 1163–1177. https://doi.org/10.1097/ALN.0b013e3182a95164

Supplemental Digital Content is available in the text.

Lumbar intrathecal injection of substance P-saporin, 15 μg, resulted in loss of neurons in the spinal cord dorsal horn expressing the neurokinin-1 receptor. A larger dose, 150 μg, resulted in progressive lower limb paresis and loss of motor neurons in the ventral horn expressing the neurokinin-1 receptor.

Anesthesiology November 2013, Vol. 119, 1178–1185. https://doi.org/10.1097/ALN.0b013e3182a95188

Substance P-saporin (SAP) is a chemical conjugate of substance P, a tachykinin neuropeptide, and saporin, a recombinant version of a ribosomal-inactivating protein, that selectively destroys superficial neurokinin-1 receptor bearing cells in the spinal dorsal horn when it is administered intrathecally. Bone cancer is commonly associated with severe pain that evolves over time and is refractory to conventional pain therapies in both dogs and humans. Seventy companion dogs with bone cancer pain were randomly assigned to receive standard analgesic therapy alone or with intrathecally administered SAP. Intrathecally administered SAP produced a time-dependent antinociceptive effect; owners requested unblinding and additional intervention by 6 weeks in 74% of control dogs and 24% of SAP-treated dogs. There was no evidence of deafferentiation in the SAP-treated dogs, but hind limb weakness and ataxia were observed in some dogs receiving cisternal injections of SAP before doses for animals with front limb tumors were decreased.

Anesthesiology November 2013, Vol. 119, 1186–1197. https://doi.org/10.1097/ALN.0b013e31829bd791

Using a muscle–nerve preparation from the rat hind paw, the authors were able to demonstrate that incision sensitizes afferent nerve fibers serving deep tissues. Acid-sensing ion channels may be responsible for this pain-related sensitization.

Anesthesiology November 2013, Vol. 119, 1198–1208. https://doi.org/10.1097/ALN.0b013e31829ce340

In mice, histone modification as one epigenetic mechanism is important to hypersensitivity after incision, and at least one epigenetic target after incision is change in CXCR2 expression.

Education: Images in Anesthesiology

Anesthesiology November 2013, Vol. 119, 1209. https://doi.org/10.1097/ALN.0b013e31827bcd9f
Anesthesiology November 2013, Vol. 119, 1210. https://doi.org/10.1097/ALN.0b013e3182815967

Education: Anesthesia Literature Review

Anesthesiology November 2013, Vol. 119, 1211–1214. https://doi.org/10.1097/ALN.0b013e3182a98d34

Education: Clinical Concepts and Commentary

Anesthesiology November 2013, Vol. 119, 1215–1221. https://doi.org/10.1097/ALN.0b013e3182a9a896

This article summarizes the current evidence for the use of gabapentinoids in the perioperative setting and provides useful clinical recommendations regarding dosing, timing, and choice of agent.

Education: Mind to Mind

Anesthesiology November 2013, Vol. 119, 1222. https://doi.org/10.1097/ALN.0b013e31828ce876
Anesthesiology November 2013, Vol. 119, 1223–1224. https://doi.org/10.1097/ALN.0b013e31829e4951
Anesthesiology November 2013, Vol. 119, 1225–1227. https://doi.org/10.1097/ALN.0b013e31829f00ae

Correspondence

Anesthesiology November 2013, Vol. 119, 1228. https://doi.org/10.1097/ALN.0b013e3182a6b3a8
Anesthesiology November 2013, Vol. 119, 1229–1230. https://doi.org/10.1097/ALN.0b013e3182a76f92
Anesthesiology November 2013, Vol. 119, 1230–1231. https://doi.org/10.1097/ALN.0b013e3182a775ce

Reviews of Educational Material

Anesthesiology November 2013, Vol. 119, 1232. https://doi.org/10.1097/ALN.0b013e3182a66d6e

Anesthesiology Reflections from the Wood Library-Museum

Anesthesiology November 2013, Vol. 119, 1010. https://doi.org/10.1097/01.anes.0000436969.64346.7a
Anesthesiology November 2013, Vol. 119, 1108. https://doi.org/10.1097/01.anes.0000436970.71969.39
Anesthesiology November 2013, Vol. 119, 1136. https://doi.org/10.1097/01.anes.0000436971.49099.81
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