Skip to Main Content

Advertisement

Skip Nav Destination

Issues

Table of Contents

Anesthesiology October 2014, Vol. 121, A13–A18. https://doi.org/10.1097/01.anes.0000453525.38098.73

Editorial Board

Anesthesiology October 2014, Vol. 121, A15–A16. https://doi.org/10.1097/01.anes.0000453524.60969.fc

This Month in Anesthesiology

Anesthesiology October 2014, Vol. 121, A3–A4. https://doi.org/10.1097/01.anes.0000453522.53345.e5

Science, Medicine, and the Anesthesiologist

Anesthesiology October 2014, Vol. 121, A19–A20. https://doi.org/10.1097/01.anes.0000453526.45722.2a

Infographics in Anesthesiology

Anesthesiology October 2014, Vol. 121, A21. https://doi.org/10.1097/01.anes.0000453527.83839.8e

Anesthesiology CME Program

Anesthesiology October 2014, Vol. 121, A17. https://doi.org/10.1097/01.anes.0000453523.53345.ac

Editorial

Anesthesiology October 2014, Vol. 121, 673–674. https://doi.org/10.1097/ALN.0000000000000400
Anesthesiology October 2014, Vol. 121, 675–677. https://doi.org/10.1097/ALN.0000000000000402
Anesthesiology October 2014, Vol. 121, 678–680. https://doi.org/10.1097/ALN.0000000000000404

Special Announcements

Anesthesiology October 2014, Vol. 121, 681–689. https://doi.org/10.1097/ALN.0000000000000385
Anesthesiology October 2014, Vol. 121, 690–691. https://doi.org/10.1097/ALN.0000000000000396
Anesthesiology October 2014, Vol. 121, 692–694. https://doi.org/10.1097/ALN.0000000000000386

Perioperative Medicine: Clinical Science

Anesthesiology October 2014, Vol. 121, 695–706. https://doi.org/10.1097/ALN.0000000000000401

Each anesthetic handover increased the risk of any major in-hospital morbidity or mortality by 8%. The adverse effects of handovers were similar for attending anesthesiologists and medically directed residents and certified registered nurse anesthetists. The adverse effects of handovers were virtually identical for residents and certified registered nurse anesthetists.

Anesthesiology October 2014, Vol. 121, 707–718. https://doi.org/10.1097/ALN.0000000000000407

Respiratory complications were twice as likely in obstructive sleep apnea patients, whether diagnosed before or after surgery, compared to controls. Patients with a preoperative diagnosis of obstructive sleep apnea and prescription for continuous positive airway pressure were less than half as likely to experience cardiovascular complications as those diagnosed after surgery.

Supplemental Digital Content is available in the text.

Anesthesiology October 2014, Vol. 121, 719–729. https://doi.org/10.1097/ALN.0000000000000392

Doppler assessment of pulmonary capillary wedge pressure (PCWP) was neither sensitive nor specific enough to be clinically useful in anesthetized and mechanically ventilated patients requiring cardiac surgery. The fixed curve pattern of the interatrial septum was the best predictor of raised PCWP only when the PCWP ≥17 mmHg.

Supplemental Digital Content is available in the text.

Anesthesiology October 2014, Vol. 121, 730–739. https://doi.org/10.1097/ALN.0000000000000375

Using a large database (44,176 adults patients undergoing noncardiac surgery), a dose-dependent renal toxicity of Hextend (high-molecular weight hydroxyethyl starch) was observed: odds ratio to develop a more serious level of acute kidney injury than crystalloids was 21% (95% CI, 6 to 38%, P < 0.001).

Anesthesiology October 2014, Vol. 121, 740–752. https://doi.org/10.1097/ALN.0000000000000376

In children without emergence delirium, an electroencephalogram pattern of sleep or drowsy states was observed before peaceful awakening. In children with emergence delirium, arousal with clinical delirium occurred before observation of electroencephalogram patterns of sleep. Frontal regional functional connectivity was significantly elevated in emergence delirium compared with that of matched controls shortly after discontinuation of anesthesia.

Perioperative Medicine: Basic Science

Anesthesiology October 2014, Vol. 121, 753–764. https://doi.org/10.1097/ALN.0000000000000315

Administration of human fibrinogen concentrates did not down-regulate endogenous porcine fibrinogen biosynthesis in this animal model.

Anesthesiology October 2014, Vol. 121, 765–772. https://doi.org/10.1097/ALN.0000000000000340

Thoracic epidural anesthesia does not decrease the tolerance to acute normovolemic anemia in healthy pigs. The hemodynamic compensation of acute anemia is fully preserved, despite sympathetic block.

Anesthesiology October 2014, Vol. 121, 773–785. https://doi.org/10.1097/ALN.0000000000000352

Cognitive function was adversely affected by anesthesia and surgery 8 days later. This adverse effect was attenuated by the systemic administration of amantadine. Amantadine increased glial cell line-derived neurotrophic factor (GDNF) levels in glia, and intracerebroventricular administration of anti-GDNF also ameliorated behavioral abnormalities. Amantadine can reduce postoperative cognitive dysfunction by increasing GDNF production and reducing surgeryinduced cerebral inflammation.

Anesthesiology October 2014, Vol. 121, 786–800. https://doi.org/10.1097/ALN.0000000000000345

Propofol induced apoptosis of human embryonic stem cell–derived neurons and reduced expression of miR-21. Overexpression of miR-21 reduced this toxicity. Neurons derived from human embryonic stem cell represent a useful model for the study of anesthetic neurotoxicity in humans. miR-21 plays a role in propofol-induced toxicity, and manipulation of miR-21 may serve as a therapeutic approach for prevention of toxicity.

Critical Care Medicine: Clinical Science

Anesthesiology October 2014, Vol. 121, 801–807. https://doi.org/10.1097/ALN.0000000000000361

In selected critically ill patients, dexmedetomidine infusions at night to achieve light levels of sedation increases sleep efficiency and modifies 24-h sleep patterns by shifting sleep to nights.

Supplemental Digital Content is available in the text.

Anesthesiology October 2014, Vol. 121, 808–816. https://doi.org/10.1097/ALN.0000000000000394

In intensive care unit patients, Anesthetic Conserving Device (ACD) (AnaConDa®; Sedana Medical AB, Uppsala, Sweden) increases the work of breathing and worsens ventilatory parameters. Sevoflurane use via the ACD with a light-sedation target normalizes respiratory parameters, and may provide an alternative method for sedation, at least, for weaning patients from mechanical ventilation.

Critical Care Medicine: Basic Science

Anesthesiology October 2014, Vol. 121, 817–824. https://doi.org/10.1097/ALN.0000000000000363

One group of animals was subjected to an 11% hemorrhage and then given either 5% albumin in a volume equal to the shed blood volume or Ringer’s acetate at 4.5 times that volume. Another group of animals was subjected to abdominal sepsis and at 3 h, measured plasma volume loss was replaced with either 5% albumin or with Ringer’s acetate in 4.5 times the measured loss. Plasma volume expansion with albumin relative to Ringer’s acetate did not differ between the two groups despite different etiologies for the decrease in plasma volume.

Pain Medicine: Clinical Science

Anesthesiology October 2014, Vol. 121, 825–834. https://doi.org/10.1097/ALN.0000000000000405

In a meta-analysis involving 18 studies and more than 4,600 patients, carriers of the G-allele were observed to exhibit higher opioid analgesic requirements. These genetic effects were strongest in Asian patients and those receiving surgery to a viscus.

Anesthesiology October 2014, Vol. 121, 835–851. https://doi.org/10.1097/ALN.0000000000000320

Aqueous extracts of Lamiophlomis rotata are effective in reducing pain-related behaviors in animal models of inflammatory, neuropathic, and cancer pain. Two components of L. rotata extracts, shanzhiside methylester (SM) and 8-O-acetyl-SM, are the principal active components. L. rotata extracts, and SM, and 8-O-acetyl-SM may work through spinal GLP-1 receptors to provide the analgesic effects.

Pain Medicine: Basic Science

Anesthesiology October 2014, Vol. 121, 852–865. https://doi.org/10.1097/ALN.0000000000000403

In a model of complex regional pain syndrome (CRPS) in mice, the animals became hypersensitive to light touch, but also exhibited behaviors indicative of anxiety and diminished working memory in some tests. These changes were accompanied by structural changes in several brain regions, suggesting that CRPS can result in broad changes in the central nervous system as well as producing pain.

Supplemental Digital Content is available in the text.

Anesthesiology October 2014, Vol. 121, 866–875. https://doi.org/10.1097/ALN.0000000000000308

A water-soluble version of the human μ-receptor was developed by mutating specific residues of the molecule. This novel receptor variant has properties similar to those of the native receptor. The development of “safe mutations” in μ-receptor will significantly advance research into the biophysical aspects of μ-receptor activation and the resulting downstream signaling.

Education: Images in Anesthesiology

Anesthesiology October 2014, Vol. 121, 876. https://doi.org/10.1097/ALN.0b013e31829f02a0
Anesthesiology October 2014, Vol. 121, 877. https://doi.org/10.1097/ALN.0b013e3182a0594b

Supplemental Digital Content is available in the text.

Education: Original Investigations in Education

Anesthesiology October 2014, Vol. 121, 878–893. https://doi.org/10.1097/ALN.0000000000000397

In a pilot study of 18 individuals recruited to assess stress at the beginning of residency, 72% consented and participated in assessments of stress, anxiety, resilience, and wellness in addition to physiological biomarkers for stress. The results provide a detailed image of stress conditions during the first months of residency as well as variability data for power analyses for hypothesis testing investigations.

Education: Clinical Concepts and Commentary

Anesthesiology October 2014, Vol. 121, 894–898. https://doi.org/10.1097/ALN.0000000000000319

Education: Mind to Mind

Anesthesiology October 2014, Vol. 121, 899. https://doi.org/10.1097/ALN.0000000000000304
Anesthesiology October 2014, Vol. 121, 900–901. https://doi.org/10.1097/ALN.0000000000000353

Correspondence

Anesthesiology October 2014, Vol. 121, 902. https://doi.org/10.1097/ALN.0000000000000378
Anesthesiology October 2014, Vol. 121, 902–903. https://doi.org/10.1097/ALN.0000000000000379
Anesthesiology October 2014, Vol. 121, 903–904. https://doi.org/10.1097/ALN.0000000000000381
Anesthesiology October 2014, Vol. 121, 904–905. https://doi.org/10.1097/ALN.0000000000000382
Anesthesiology October 2014, Vol. 121, 905–906. https://doi.org/10.1097/ALN.0000000000000388
Anesthesiology October 2014, Vol. 121, 906. https://doi.org/10.1097/ALN.0000000000000389
Anesthesiology October 2014, Vol. 121, 906–907. https://doi.org/10.1097/ALN.0000000000000390

Reviews of Educational Material

Anesthesiology October 2014, Vol. 121, 908. https://doi.org/10.1097/ALN.0000000000000237
Anesthesiology October 2014, Vol. 121, 908–909. https://doi.org/10.1097/ALN.0000000000000309

Anesthesiology Reflections from the Wood Library-Museum

Anesthesiology October 2014, Vol. 121, 834. https://doi.org/10.1097/01.anes.0000453528.91463.39
Anesthesiology October 2014, Vol. 121, 865. https://doi.org/10.1097/01.anes.0000453529.68592.0d
Anesthesiology October 2014, Vol. 121, 893. https://doi.org/10.1097/01.anes.0000453530.68592.db
Close Modal

or Create an Account

Close Modal
Close Modal