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Volume 127, Issue 5

November 2017

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In this Issue

Table of Contents
Editorial Board
This Month in Anesthesiology
Science, Medicine, and the Anesthesiologist
Infographics in Anesthesiology
Anesthesiology CME Program
Editorial
Special Articles
Perioperative Medicine: Clinical Science
Perioperative Medicine: Basic Science
Critical Care Medicine: Basic Science
Pain Medicine: Basic Science
Education: Images in Anesthesiology
Education: Mind to Mind
Correspondence
Reviews of Educational Material
Anesthesiology Reflections from the Wood Library-Museum

Anesthesiology

Anesthesiology November 2017, Vol. 127, A3–A7. https://doi.org/10.1097/ALN.0000000000001945

View Articletitled, Anesthesiology

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Editorial Board

Anesthesiology

Anesthesiology November 2017, Vol. 127, A11–A12. https://doi.org/10.1097/ALN.0000000000001916

View Articletitled, Anesthesiology

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This Month in Anesthesiology

This Month in: Anesthesiology

Anesthesiology November 2017, Vol. 127, A1–A2. https://doi.org/10.1097/ALN.0000000000001924

View Articletitled, This Month in: Anesthesiology

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Science, Medicine, and the Anesthesiologist

Anesthesiology November 2017, Vol. 127, A15–A18. https://doi.org/10.1097/ALN.0000000000001917

View Articletitled, Science, Medicine, and the Anesthesiologist

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Infographics in Anesthesiology

Preoperative Cognitive Dysfunction: It’s More Common Than You Think

Jonathan P. Wanderer; James P. Rathmell

Anesthesiology November 2017, Vol. 127, A19. https://doi.org/10.1097/ALN.0000000000001918

View Articletitled, Preoperative Cognitive Dysfunction: It’s More Common Than You Think

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Topics: cognitive impairment , preoperative care

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

Anesthesiology November 2017, Vol. 127, A13. https://doi.org/10.1097/ALN.0000000000001900

View Articletitled, Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

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Editorial

Errors and Integrity in Seeking and Reporting Apparent Research Misconduct

Evan D. Kharasch, M.D., Ph.D.; Timothy T. Houle, Ph.D.

Anesthesiology November 2017, Vol. 127, 733–737. https://doi.org/10.1097/ALN.0000000000001875

View Articletitled, Errors and Integrity in Seeking and Reporting Apparent Research Misconduct

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Topics: personal integrity

Promoting Safety, Quality, and Value through Patient Blood Management

Jonathan H. Waters, M.D.

Anesthesiology November 2017, Vol. 127, 738–740. https://doi.org/10.1097/ALN.0000000000001876

View Articletitled, Promoting Safety, Quality, and Value through Patient Blood Management

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Topics: safety

MAC Meeting MIGET: Leaps of Faith

Jan F. A. Hendrickx, M.D., Ph.D.; Philip J. Peyton, M.D., Ph.D., M.B.B.S., F.A.N.Z.C.A.; Andre M. De Wolf, M.D.

Anesthesiology November 2017, Vol. 127, 741–743. https://doi.org/10.1097/ALN.0000000000001848

View Articletitled, MAC Meeting MIGET: Leaps of Faith

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Topics: minimum alveolar concentration

Precision Correction of Coagulopathy or Prothrombin Complex Concentrates?: Reversal Options for Dabigatran following Trauma

Matthew D. Neal, M.D.; Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M.

Anesthesiology November 2017, Vol. 127, 744–746. https://doi.org/10.1097/ALN.0000000000001857

View Articletitled, Precision Correction of Coagulopathy or Prothrombin Complex Concentrates?: Reversal Options for Dabigatran following Trauma

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Topics: blood coagulation disorders , dabigatran etexilate , factor ix concentrates , precision , wounds and injuries

Special Articles

Earliest English Definitions of Anaisthesia and Anaesthesia

Rajesh P. Haridas, M.B.Ch.B., F.A.N.Z.C.A.

Anesthesiology November 2017, Vol. 127, 747–753. https://doi.org/10.1097/ALN.0000000000001764

View Articletitled, Earliest English Definitions of Anaisthesia and Anaesthesia

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Topics: dictionaries

Perioperative Medicine: Clinical Science

Implementing a Health System–wide Patient Blood Management Program with a Clinical Community Approach

Steven M. Frank, M.D.; Rajiv N. Thakkar, M.D.; Stanley J. Podlasek, M.D.; K. H. Ken Lee, Dr.PH., M.H.S.; Tyler L. Wintermeyer, M.S.; Will W. Yang, B.S.; Jing Liu, Ph.D.; Leo C. Rotello, M.D.; Thomas A. Fleury, M.D.; Pat A. Wachter, M.A.; Lisa E. Ishii, M.D.; Renee Demski, M.S.W., M.B.A.; Peter J. Pronovost, M.D., Ph.D.; Paul M. Ness, M.D.

Anesthesiology November 2017, Vol. 127, 754–764. https://doi.org/10.1097/ALN.0000000000001851

View Articletitled, Implementing a Health System–wide Patient Blood Management Program with a Clinical Community Approach

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Topics: community , health care systems , pharmacy benefits managers , transfusion

Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients

Deborah J. Culley, M.D.; Devon Flaherty, M.D., M.P.H.; Margaret C. Fahey, M.A.; James L. Rudolph, M.D.; Houman Javedan, M.D.; Chuan-Chin Huang, Ph.D.; John Wright, M.D.; Angela M. Bader, M.D., M.P.H.; Bradley T. Hyman, M.D., Ph.D.; Deborah Blacker, M.D., Sc.D.; Gregory Crosby, M.D.

Anesthesiology November 2017, Vol. 127, 765–774. https://doi.org/10.1097/ALN.0000000000001859

View Articletitled, Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients

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Topics: mini-cog , orthopedics , postoperative complications , preoperative care , screening test

Clinical Effectiveness of Intravenous Exenatide Infusion in Perioperative Glycemic Control after Coronary Artery Bypass Graft Surgery: A Phase II/III Randomized Trial

Guillaume Besch, M.D.; Andrea Perrotti, M.D., Ph.D.; Frederic Mauny, M.D., Ph.D.; Marc Puyraveau, M.Sc.; Maude Baltres, M.D.; Guillaume Flicoteaux, M.D.; Lucie Salomon du Mont, M.D.; Benoit Barrucand, M.D.; Emmanuel Samain, M.D., Ph.D.; Sidney Chocron, M.D., Ph.D.; Sebastien Pili-Floury, M.D., Ph.D.

Anesthesiology November 2017, Vol. 127, 775–787. https://doi.org/10.1097/ALN.0000000000001838

View Articletitled, Clinical Effectiveness of Intravenous Exenatide Infusion in Perioperative Glycemic Control after Coronary Artery Bypass Graft Surgery: A Phase II/III Randomized Trial

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Topics: coronary artery bypass surgery , exenatide , infusion procedures , insulin , hypoglycemia

Are Anesthesia and Surgery during Infancy Associated with Decreased White Matter Integrity and Volume during Childhood?

Robert I. Block, Ph.D.; Vincent A. Magnotta, Ph.D.; Emine O. Bayman, Ph.D.; James Y. Choi, M.D.; Joss J. Thomas, M.D.; Karolie K. Kimble, R.N., B.A.

Anesthesiology November 2017, Vol. 127, 788–799. https://doi.org/10.1097/ALN.0000000000001808

View Articletitled, Are Anesthesia and Surgery during Infancy Associated with Decreased White Matter Integrity and Volume during Childhood?

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Topics: child , infant , magnetic resonance imaging , personal integrity , surgery specialty

Perioperative Medicine: Basic Science

Effect of Bronchoconstriction-induced Ventilation–Perfusion Mismatch on Uptake and Elimination of Isoflurane and Desflurane

Moritz Kretzschmar, M.D., Ph.D., D.E.S.A.; Alf Kozian, M.D., Ph.D.; James E. Baumgardner, M.D., Ph.D.; Joao Batista Borges, M.D., Ph.D.; Göran Hedenstierna, M.D., Ph.D.; Anders Larsson, M.D., Ph.D., D.E.A.A.; Thomas Hachenberg, M.D., Ph.D.; Thomas Schilling, M.D., Ph.D., D.E.A.A.

Anesthesiology November 2017, Vol. 127, 800–812. https://doi.org/10.1097/ALN.0000000000001847

View Articletitled, Effect of Bronchoconstriction-induced Ventilation–Perfusion Mismatch on Uptake and Elimination of Isoflurane and Desflurane

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Topics: bronchoconstriction , desflurane , isoflurane , methacholine , ventilation-perfusion mismatching

Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents

Andras Garami, M.D., Ph.D.; Mohab Ibrahim, M.D., Ph.D.; Kerry Gilbraith, B.S.; Rajesh Khanna, Ph.D.; Eszter Pakai, M.S.; Alexandra Miko, M.D.; Erika Pinter, M.D., Ph.D., D.Sc.; Andrej A. Romanovsky, M.D., Ph.D.; Frank Porreca, Ph.D.; Amol M. Patwardhan, M.D., Ph.D.

Anesthesiology November 2017, Vol. 127, 813–823. https://doi.org/10.1097/ALN.0000000000001812

View Articletitled, Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents

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Topics: antagonists , hypothermia due to anesthetic , hypothermia, induced , hypothermia, natural , ketamine

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy

Celena Ma, B.S.; Ervin Pejo, B.S.; Megan McGrath, B.S.; Selwyn S. Jayakar, Ph.D.; Xiaojuan Zhou, Ph.D.; Keith W. Miller, D.Phil.; Jonathan B. Cohen, Ph.D.; Douglas E. Raines, M.D.

Anesthesiology November 2017, Vol. 127, 824–837. https://doi.org/10.1097/ALN.0000000000001840

View Articletitled, Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy

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Topics: etomidate , gamma-aminobutyric acid , naphthalenes , gaba-a receptor , propofol

Disruption of Hippocampal Multisynaptic Networks by General Anesthetics

Min-Ching Kuo, Ph.D.; L. Stan Leung, Ph.D.

Anesthesiology November 2017, Vol. 127, 838–851. https://doi.org/10.1097/ALN.0000000000001861

View Articletitled, Disruption of Hippocampal Multisynaptic Networks by General Anesthetics

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Topics: hippocampus , isoflurane , anesthetics, general , pulse , dendrites

Critical Care Medicine: Basic Science

Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma

Markus Honickel, M.D.; Till Braunschweig, M.D.; Rolf Rossaint, M.D.; Christian Stoppe, M.D.; Hugo ten Cate, M.D., Ph.D.; Oliver Grottke, M.D., Ph.D.

Anesthesiology November 2017, Vol. 127, 852–861. https://doi.org/10.1097/ALN.0000000000001856

View Articletitled, Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma

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Topics: anticoagulation , dabigatran etexilate , factor ix concentrates , fibrinogen , hemorrhage

Pain Medicine: Basic Science

Bromodomain-containing Protein 4 Activates Voltage-gated Sodium Channel 1.7 Transcription in Dorsal Root Ganglia Neurons to Mediate Thermal Hyperalgesia in Rats

Ming-Chun Hsieh, M.Sc.; Yu-Cheng Ho, Ph.D.; Cheng-Yuan Lai, B.S.; Hsueh-Hsiao Wang, Ph.D.; An-Sheng Lee, Ph.D.; Jen-Kun Cheng, M.D., Ph.D.; Yat-Pang Chau, Ph.D.; Hsien-Yu Peng, Ph.D.

Anesthesiology November 2017, Vol. 127, 862–877. https://doi.org/10.1097/ALN.0000000000001809

View Articletitled, Bromodomain-containing Protein 4 Activates Voltage-gated Sodium Channel 1.7 Transcription in Dorsal Root Ganglia Neurons to Mediate Thermal Hyperalgesia in Rats

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Topics: ganglia, spinal , hyperalgesia , neurons , rats , voltage-gated sodium channels

Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation

Fiona A. Bull, Ph.D.; Daniel T. Baptista-Hon, Ph.D.; Claire Sneddon, B.Sc.; Lisa Wright, B.Sc.; Wendy Walwyn, Ph.D.; Tim G. Hales, Ph.D.

Anesthesiology November 2017, Vol. 127, 878–889. https://doi.org/10.1097/ALN.0000000000001834

View Articletitled, Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation

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Topics: morphine , mice , phosphotransferases , dasatinib , analgesics

Education: Images in Anesthesiology

Images in Anesthesiology: Air Embolism during Cardiac Catheterization and the Role for Anesthesia Use of Bedside Ultrasound

Adam C. Adler, M.S., M.D., F.A.A.P.

Anesthesiology November 2017, Vol. 127, 890. https://doi.org/10.1097/ALN.0000000000001712

View Articletitled, Images in Anesthesiology: Air Embolism during Cardiac Catheterization and the Role for Anesthesia Use of Bedside Ultrasound

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Topics: air embolism , cardiac catheterization , scanning systems, ultrasonic, portable

Lingual Thyroid

Bikram Kishore Behera, M.D.; Satyajeet Misra, M.D., D.N.B., P.D.C.C., T.E.E. Certified (E.A.C.V.I.), F.T.E.E.; Pradipta Kumar Parida, M.S., D.N.B.

Anesthesiology November 2017, Vol. 127, 891. https://doi.org/10.1097/ALN.0000000000001743

View Articletitled, Lingual Thyroid

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Topics: lingual thyroid

Fulminant Hyperfibrinolysis Diagnosed by Rotational Thromboelastometry

John S. McNeil, M.D.; Amanda M. Kleiman, M.D.

Anesthesiology November 2017, Vol. 127, 892. https://doi.org/10.1097/ALN.0000000000001742

View Articletitled, Fulminant Hyperfibrinolysis Diagnosed by Rotational Thromboelastometry

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Topics: activated partial thromboplastin time measurement , alteplase , antifibrinolytic agents , aprotinin , blood coagulation

Education: Mind to Mind

Still Beauty

Allison L. Thoeny, M.D.

Anesthesiology November 2017, Vol. 127, 893. https://doi.org/10.1097/ALN.0000000000001822

View Articletitled, Still Beauty

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Topics: beauty

Losing My Favorite Anesthesiologist

Terrance A. Yemen, M.D., F.R.C.P. (C)

Anesthesiology November 2017, Vol. 127, 894–895. https://doi.org/10.1097/ALN.0000000000001821

View Articletitled, Losing My Favorite Anesthesiologist

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Topics: father , heart , love , mothers , teasing

Correspondence

Muscle Relaxation and Lower Airway Characteristics May Affect Tidal Volume during Pressure-controlled Ventilation

Zhiqiang Zhou, M.D.; Xueren Wang, M.D., Ph.D.

Anesthesiology November 2017, Vol. 127, 896. https://doi.org/10.1097/ALN.0000000000001826

View Articletitled, Muscle Relaxation and Lower Airway Characteristics May Affect Tidal Volume during Pressure-controlled Ventilation

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Rocuronium Onset May Affect Mask Ventilation

Lei Wang, M.D.; Lingxin Wei, M.D.

Anesthesiology November 2017, Vol. 127, 896–897. https://doi.org/10.1097/ALN.0000000000001827

View Articletitled, Rocuronium Onset May Affect Mask Ventilation

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“Loose Lips Are Actually Good”

Charles W. Buffington, M.D.; Cynthia M. Q. Wells, M.D.; Ryan J. Soose, M.D.

Anesthesiology November 2017, Vol. 127, 897. https://doi.org/10.1097/ALN.0000000000001828

View Articletitled, “Loose Lips Are Actually Good”

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In Reply

Shiroh Isono, M.D.; Shin Sato, M.D.; Makoto Hasegawa, M.D.; Megumi Okuyama, M.D.; Junko Okazaki, M.D.; Yuji Kitamura, M.D.; Yumi Sato, M.D.; Teruhiko Ishikawa, M.D.; Yasunori Sato, Ph.D.

Anesthesiology November 2017, Vol. 127, 897–898. https://doi.org/10.1097/ALN.0000000000001829

View Articletitled, In Reply

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Insulin for Perioperative Glucose Control: Settled Science?

Rebecca Gerlach, M.D., F.R.C.P.C.; Avery Tung, M.D., F.C.C.M.

Anesthesiology November 2017, Vol. 127, 899–900. https://doi.org/10.1097/ALN.0000000000001845

View Articletitled, Insulin for Perioperative Glucose Control: Settled Science?

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In Reply

Elizabeth W. Duggan, M.D.; Guillermo E. Umpierrez, M.D., C.D.E.

Anesthesiology November 2017, Vol. 127, 900–901. https://doi.org/10.1097/ALN.0000000000001846

View Articletitled, In Reply

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When Managing Patients with Left Ventricular Assist Devices Undergoing Noncardiac Surgery, Less Is Not More

Robert E. Freundlich, M.D., M.S.; Adam J. Kingeter, M.D.

Anesthesiology November 2017, Vol. 127, 901–902. https://doi.org/10.1097/ALN.0000000000001852

View Articletitled, When Managing Patients with Left Ventricular Assist Devices Undergoing Noncardiac Surgery, Less Is Not More

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Noninvasive Blood Pressure Determination in Left Ventricular Assist Device Patients

David W. Barbara, M.D.; Troy G. Seelhammer, M.D.; William J. Mauermann, M.D.

Anesthesiology November 2017, Vol. 127, 902–903. https://doi.org/10.1097/ALN.0000000000001853

View Articletitled, Noninvasive Blood Pressure Determination in Left Ventricular Assist Device Patients

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In Reply

Michael R. Mathis, M.D.; Subramanian Sathishkumar, M.B.B.S.; Milo C. Engoren, M.D.

Anesthesiology November 2017, Vol. 127, 903–904. https://doi.org/10.1097/ALN.0000000000001854

View Articletitled, In Reply

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A Deeper Look at Anesthesia Depth

Robert M. Knapp, D.O., J.D.

Anesthesiology November 2017, Vol. 127, 904–905. https://doi.org/10.1097/ALN.0000000000001849

View Articletitled, A Deeper Look at Anesthesia Depth

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Amendments and Corrections to Mattusch et al. (Anesthesiology 2015; 122[5]:1047–59), “Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments”

Stephan Kratzer, M.D.; Rainer Haseneder, M.D.; Peter A. Goldstein, M.D.; Eberhard Kochs, M.D.; Gerhard Rammes, Ph.D.

Anesthesiology November 2017, Vol. 127, 905–910. https://doi.org/10.1097/ALN.0000000000001830

View Articletitled, Amendments and Corrections to Mattusch et al. (Anesthesiology 2015; 122[5]:1047–59), “Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments”

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Reviews of Educational Material

Paediatric Anaesthetic Emergency Data Manual

Samuel H. Wald, M.D., M.B.A.

Anesthesiology November 2017, Vol. 127, 911. https://doi.org/10.1097/ALN.0000000000001844

View Articletitled, Paediatric Anaesthetic Emergency Data Manual

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Topics: pediatrics

Anesthesiology Reflections from the Wood Library-Museum

Queen Victoria’s Youngest Two Sons: Princes Arthur and Leopold

Anesthesiology November 2017, Vol. 127, 740. https://doi.org/10.1097/ALN.0000000000001901

View Articletitled, Queen Victoria’s Youngest Two Sons: Princes Arthur and Leopold

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Picturing “Dr. Colton” at the Cooper Institute: His Honorific Doctorate

Anesthesiology November 2017, Vol. 127, 743. https://doi.org/10.1097/ALN.0000000000001902

View Articletitled, Picturing “Dr. Colton” at the Cooper Institute: His Honorific Doctorate

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Awnings before Yawnings: Advertising Anesthetic Stupor at “the Cooper”

Anesthesiology November 2017, Vol. 127, 746. https://doi.org/10.1097/ALN.0000000000001903

View Articletitled, Awnings before Yawnings: Advertising Anesthetic Stupor at “the Cooper”

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Sharing “Beta-Eucain” with Schering: Albrecht Schmidt and George Merling

Anesthesiology November 2017, Vol. 127, 764. https://doi.org/10.1097/ALN.0000000000001904

View Articletitled, Sharing “Beta-Eucain” with Schering: Albrecht Schmidt and George Merling

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Presidential Perforations? James T. Gwathmey, M.D., Modifies Yankauer Masks

Anesthesiology November 2017, Vol. 127, 774. https://doi.org/10.1097/ALN.0000000000001905

View Articletitled, Presidential Perforations? James T. Gwathmey, M.D., Modifies Yankauer Masks

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Chicago Art Institute Alumnus Dalton Stevens Covers a Criminal Chloroforming

Anesthesiology November 2017, Vol. 127, 837. https://doi.org/10.1097/ALN.0000000000001906

View Articletitled, Chicago Art Institute Alumnus Dalton Stevens Covers a Criminal Chloroforming

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Issues

Cover Image

Table of Contents

Editorial Board

This Month in Anesthesiology

Science, Medicine, and the Anesthesiologist

Infographics in Anesthesiology

Anesthesiology CME Program

Editorial

Special Articles

Perioperative Medicine: Clinical Science

Perioperative Medicine: Basic Science

Critical Care Medicine: Basic Science

Pain Medicine: Basic Science

Education: Images in Anesthesiology

Education: Mind to Mind

Correspondence

Reviews of Educational Material

Anesthesiology Reflections from the Wood Library-Museum

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